Journal ArticleDOI
Human JC polyomavirus in normal colorectal mucosa, hyperplastic polyps, sporadic adenomas, and adenocarcinomas in Portugal.
Tatiana Rasteiro Coelho,Rita Gaspar,Pedro Figueiredo,Cristina Mendonça,Pedro A. Lazo,Luis Almeida +5 more
TLDR
John Cunningham virus (JCV) may have a specific tropism for colon epithelial cells with some inherent predisposition that makes them more prone to oncogenic transformation, with selection of infected cells.Abstract:
John Cunningham virus (JCV) infects chronically human populations worldwide and probably might confer a higher risk for colorectal cancer (CRC). The prevalence of JCV DNA has been determined in normal colon mucosa and compared it with different degrees of colorectal lesions, as well as viral presence in the urine of the individuals in the study. JCV DNA was detected by a nested-PCR approach targeting the JCV small-t antigen in 100 healthy controls, and 100 patients undergoing biopsy for diagnosis of colorectal disorders. JCV DNA was detected in 40% of normal mucosa from controls and patients. JCV DNA presence in urine was also similar in controls and patients (37-41% range). JCV DNA detection in normal mucosa and urine reflects the infected population in Portugal. However, in cases with colorectal tumor lesions, JCV DNA was detected in 90% cases, independently of histological type or grade, and this increase was significantly higher with respect to its normal surrounding mucosa. This higher detection of JCV DNA in tumor lesions with respect to its own normal mucosa suggested that a selection for virus containing cells has occurred at some early stage in tumor initiation or progression. JCV may have a specific tropism for colon epithelial cells with some inherent predisposition that makes them more prone to oncogenic transformation, with selection of infected cells. Several p53 polymorphisms in intron 2, common to both groups, were more frequently detected in colorectal pathology cases. A novel p53 mutation in the 3' untranslated region (exon 11) was identified in 10 patients.read more
Citations
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Journal ArticleDOI
Viral infections and colorectal cancer: a systematic review of epidemiological studies
TL;DR: Overall published evidence on the role of viral infections in CRC etiology remains limited and there is a strong need for large, methodologically rigorous epidemiological studies on the association between viral infections and CRC.
Journal ArticleDOI
Human polyomaviruses and cancer: an overview.
José Carlos Mann Prado,T A Monezi,Aline T. Amorim,Vanesca de Souza Lino,Andressa Paladino,Enrique Boccardo +5 more
TL;DR: Present evidence only supports the role of MCPyV as a carcinogen to humans, and a summarized discussion on the current knowledge concerning the roleof MCPYV, TSPyV, JCPy V and BKPyV in human cancers is presented.
Journal ArticleDOI
Early onset sporadic colorectal cancer: Worrisome trends and oncogenic features.
Giulia Martina Cavestro,Alessandro Mannucci,Raffaella Alessia Zuppardo,Milena Di Leo,Elena M. Stoffel,Giovanni Tonon +5 more
TL;DR: Genome-wide hypomethylation is a feature of a subgroup of early onset cancers, which appears to be correlated with chromosomal instability and poor prognosis, with most of the early onset colorectal cancers exhibiting microsatellite stable phenotypes.
Journal ArticleDOI
Activation of c-Myc and Cyclin D1 by JCV T-Antigen and β-catenin in colon cancer.
Michael Ripple,Amanda P. Struckhoff,Jimena Trillo-Tinoco,Li Li,David A. Margolin,Robin R McGoey,Luis Del Valle +6 more
TL;DR: Investigation of the association of T-Antigen and nuclear β-catenin in colon cancer cases and the effects of this complex in the activation of the transcription and cell cycle regulators c-Myc and Cyclin D1 in vitro provides further evidence for a role of JCV T- Antigen in the dysregulation of the Wnt signaling pathway and in the pathogenesis of colon cancer.
Journal ArticleDOI
JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract
Luigi Ricciardiello,Luigi Lagbi,Pradeep Ramamirtham,Christina L. Chang,Dong K. Chang,A.E. Randolph,C. Richard Boland +6 more
TL;DR: The results show that JCV DNA sequences are highly prevalent in the human upper and lower gastrointestinal tract of immunocompetent individuals.
References
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