Journal ArticleDOI
Papillomaviruses and cancer: from basic studies to clinical application
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TLDR
Links between human papillomaviruses (HPVs) and cervical cancer were first suspected almost 30 years ago and DNA of specific HPV types has since been found in almost all cervical cancer biopsies.Abstract:
Links between human papillomaviruses (HPVs) and cervical cancer were first suspected almost 30 years ago. DNA of specific HPV types has since been found in almost all cervical cancer biopsies. HPV oncogenes that are expressed in these cells are involved in their transformation and immortalization, and are required for the progression towards malignancy. Epidemiological studies have underlined that HPVs are the main aetiological factor for cervical cancer. But how has this knowledge been translated into the clinic to allow the prevention, screening and treatment of cervical cancer?read more
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Classification of papillomaviruses
Ethel Michele De Villiers,Claude M. Fauquet,Thomas R. Broker,Hans-Ulrich Bernard,Harald zur Hausen +4 more
TL;DR: The higher-order PV taxonomy is described following the general criteria established by the International Committee on the Taxonomy of Viruses (ICTV), reviews the literature of the lower order taxa, lists all known "PV types", and interprets their phylogenetic relationship.
Journal ArticleDOI
The molecular biology of head and neck cancer
TL;DR: The recent literature on tumour heterogeneity, field cancerization, molecular pathogenesis and the underlying causative cancer genes that can be exploited for novel and personalized treatments of patients with HNSCC are discussed.
Journal ArticleDOI
RNAscope: A Novel in Situ RNA Analysis Platform for Formalin-Fixed, Paraffin-Embedded Tissues
Fai Wang,John G. Flanagan,Nan Su,Li Chong Wang,Son Bui,Allissa Nielson,Xingyong Wu,Hong Thuy Vo,Xiao Jun Ma,Yuling Luo +9 more
TL;DR: RNAscope is described, a novel RNA ISH technology with a unique probe design strategy that allows simultaneous signal amplification and background suppression to achieve single-molecule visualization while preserving tissue morphology and may enable rapid development of RNAISH-based molecular diagnostic assays.
Journal ArticleDOI
Human papillomavirus oncoproteins: pathways to transformation
TL;DR: Understanding how HPV oncoproteins modify these activities provides novel insights into the basic mechanisms of oncogenesis, which are crucial regulators of cell cycle progression, telomere maintenance, apoptosis and chromosomal stability.
Journal ArticleDOI
Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis.
Silvia de Sanjosé,Mireia Diaz,Xavier Castellsagué,Gary M. Clifford,Laia Bruni,Nubia Muñoz,F. Xavier Bosch +6 more
TL;DR: The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women.
References
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Journal ArticleDOI
Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective
Francesc Xavier Bosch,M. M. Manos,Nubia Muñoz,Mark E. Sherman,Angela M. Jansen,Julian Peto,Mark Schiffman,Victor Moreno,Robert J. Kurman,Keerti V. Shah +9 more
TL;DR: The results confirm the role of genitalHPVs, which are transmitted sexually, as the central etiologic factor in cervical cancer worldwide and suggest that most genital HPVs are associated with cancer, at least occasionally.
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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
TL;DR: The results suggest that these three DNA viruses may utilize similar mechanisms in transformation and implicate RB binding as a possible step in human papilloma virus-associated carcinogenesis.
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Association of human papillomavirus types 16 and 18 E6 proteins with p53.
TL;DR: This study shows that the E6 protein of HPV-16 is capable of binding to the cellular p53 protein, providing further evidence that the human papillomaviruses, the adenovirus type 5, and SV40 may effect similar cellular pathways in transformation.
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A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.
TL;DR: The data indicate that HPV 16 DNA prevails in malignant tumors, rendering an accidental contamination with papillomavirus DNA from adjacent papillomas rather unlikely, and suggests a dependence of HPV 16 replication on helper virus.
Journal ArticleDOI
Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group.
Mei-Hwei Chang,Chien-Jen Chen,Mei-Shu Lai,Hsu-Mei Hsu,Tzee-Chung Wu,Man-Shan Kong,Der-Cherng Liang,Wen-Yi Shau,Ding-Shinn Chen +8 more
TL;DR: The incidence of hepatocellular carcinoma in children in Taiwan from 1981 to 1994 has declined since the institution of Taiwan's program of universal hepatitis B vaccination, and the corresponding rates of mortality have decreased.