Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma
John O. Ogunbileje,Craig Porter,David N. Herndon,Tony Chao,Doaa Reda Abdelrahman,Doaa Reda Abdelrahman,Anastasia Papadimitriou,Maria Chondronikola,Teresa A. Zimmers,Paul T. Reidy,Blake B. Rasmussen,Labros S. Sidossis +11 more
TLDR
It is found that burn patients were profoundly hypermetabolic at both the skeletal muscle and systemic levels, indicating increased oxygen consumption by mitochondria and a novel role for the mitochondria in burn-induced cachexia.Abstract:
Burn trauma results in prolonged hypermetabolism and skeletal muscle wasting. How hypermetabolism contributes to muscle wasting in burn patients remains unknown. We hypothesized that oxidative stre...read more
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The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury.
TL;DR: In this paper, the effect of the PARP inhibitor olaparib (10 mg/kg/day i.p) in a murine model of burn injury was investigated.
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Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia
TL;DR: This review focuses on the current state of the field on the role of inflammation and OS in the pathogenesis of muscle atrophy during CC, and how nutraceuticals and physical activity may act synergistically to limit muscle wasting and dysfunction.
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Metabolismo y terapia nutricional en el paciente quemado crítico: una revisión actualizada
TL;DR: En las ultimas 4 decadas se han estudiado diferentes intervenciones nutricionales y farmacologicas moduladoras de la respuesta inmune y metabolica, y dichas estrategias han demostrado ser capaces de minimizar the malnutricion aguda, modular the respUesta inmunoinflamatoria y mejorar los resultados clinicos.
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Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury
Eliana Baez-Jurado,Gina Guio-Vega,Oscar Hidalgo-Lanussa,Janneth Gonzalez,Valentina Echeverria,Ghulam Md Ashraf,Amirhossein Sahebkar,George E. Barreto +7 more
TL;DR: Regulation of brain inflammation combined with the recovery of fundamental cellular aspects in the face of injury makes CM-hMSCA a promising candidate for the protection of astrocytes in brain pathologies.
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Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation
Harumasa Nakazawa,Harumasa Nakazawa,Harumasa Nakazawa,Kazuhiro Ikeda,Shohei Shinozaki,Shohei Shinozaki,Shohei Shinozaki,Masayuki Kobayashi,Masayuki Kobayashi,Yuichi Ikegami,Ming Fu,Ming Fu,Tomoyuki Nakamura,Tomoyuki Nakamura,Shingo Yasuhara,Shingo Yasuhara,Yong-Ming Yu,Yong-Ming Yu,J. A. Jeevendra Martyn,J. A. Jeevendra Martyn,Ronald G. Tompkins,Ronald G. Tompkins,Kentaro Shimokado,Tomoko Yorozu,Hideki Ito,Satoshi Inoue,Masao Kaneki,Masao Kaneki +27 more
TL;DR: Protein farnesylation is identified as a potential hub of the signaling network affecting multiple aspects of metabolic alterations after burn injury and as a novel potential molecular target to improve the clinical outcome of severely burned patients.
References
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