Journal ArticleDOI
Identification and Chemical Synthesis of a Host Cell Receptor Binding Site on Hepatitis B Virus
Reads0
Chats0
TLDR
A synthetic peptide analog is recognized by both cell receptors and anti-HBV antibodies and elicits antibodies reacting with native HBV, and is a promising immunogen expected to elicit protective antibodies based on the concept of the attachment blockade pathway of virus neutralization.About:
This article is published in Cell.The article was published on 1986-08-01. It has received 536 citations till now. The article focuses on the topics: Peptide analog & Hepatitis B virus.read more
Citations
More filters
Journal ArticleDOI
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain.
Colin M. House,Bruce E. Kemp +1 more
TL;DR: It is demonstrated that the conserved region of the regulatory domain of protein kinase C has the secondary structural features of a pseudosubstrate and may be responsible for maintaining the enzyme in the inactive form in the absence of allosteric activators such as phospholipids.
Journal ArticleDOI
The antigenic index a novel algorithm for predicting antigenic determinants
B. A. Jameson,Hans Wolf +1 more
TL;DR: A computer algorithm is introduced which can be used to predict the topological features of a protein directly from its primary amino acid sequence and a strong correlation between the predictions of the antigenic index and known structural and biological data is found.
Journal ArticleDOI
Hepatitis B vaccines.
TL;DR: Yeast-derived hepatitis B vaccines, containing the small HBV envelope protein SHBAg, are immunogenic, safe and cost-effective in prevention of hepatitis B virus infection in neonates, children and adults.
Journal ArticleDOI
Update on Diagnosis, Management, and Prevention of Hepatitis B Virus Infection
TL;DR: Significant progress in the understanding of the molecular virology and pathogenesis of HBV infection has been made and effective treatment modalities have been developed for persons with chronic infection.
Journal ArticleDOI
Polyvalente Wechselwirkungen in biologischen Systemen: Auswirkungen auf das Design und die Verwendung multivalenter Liganden und Inhibitoren
TL;DR: In this article, polyvalent Wechselwirkungen viel starker sein als entsprechende monovalente Wechwirthungen, and sie konnen die Basis fur das Verstandnis fordernder und hemmender biologischer Wechungungen liefern, die sich grundsatzlich von denen in monovalenten Systemen unterscheiden.
References
More filters
Journal ArticleDOI
Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity
TL;DR: It was found that treatment of gels with dithiothreitol prior to impregnation with silver nitrate results in more reproducible staining patterns that are also qualitatively similar to those obtained with Coomassie blue.
Journal ArticleDOI
Rapid and sensitive protein similarity searches
TL;DR: An algorithm was developed which facilitates the search for similarities between newly determined amino acid sequences and sequences already available in databases and increases sensitivity by giving high scores to those amino acid replacements which occur frequently in evolution.
Journal ArticleDOI
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
TL;DR: The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of antiparallel β-sheet is positioned on top of this stem.
Journal ArticleDOI
Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.
TL;DR: Analysis of the cell culture fluid from two new human hepatoma-derived cell lines reveals that 17 of the major human plasma proteins are synthesized and secreted by these cells.
Journal ArticleDOI
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation
TL;DR: Four ‘antigenic sites’ on the three-dimensional structure of the influenza haemagglutinin are identified and at least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.