Journal ArticleDOI
Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain.
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TLDR
In this article, the 23rd documented FGF, FGF-23 has a hydrophobic amino terminus (approximately 24 amino acids), which is a typical signal sequence, and was found to be preferentially expressed in the ventrolateral thalamic nucleus.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2000-10-22. It has received 538 citations till now. The article focuses on the topics: Amino acid & Peptide sequence.read more
Citations
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Journal ArticleDOI
Fibroblast growth factors
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
Journal ArticleDOI
The FGF family: biology, pathophysiology and therapy.
Andrew Beenken,Moosa Mohammadi +1 more
TL;DR: Traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in thetreatment of metabolic syndrome and hypophosphataemic diseases are discussed.
Journal ArticleDOI
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
Takashi Shimada,Satoru Mizutani,Takanori Muto,Takashi Yoneya,Rieko Hino,Shu Takeda,Yasuhiro Takeuchi,Toshiro Fujita,Seiji Fukumoto,Takeyoshi Yamashita +9 more
TL;DR: It is concluded that overproduction of F GF23 causes TIO, whereas mutations in the FGF23 gene result in autosomal dominant hypophosphatemic rickets possibly by preventing proteolytic cleavage and enhancing biological activity of FGF 23.
Journal ArticleDOI
Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia.
Kenneth B. Jonsson,Richard J. Zahradnik,Tobias E. Larsson,Kenneth E. White,Toshitsugu Sugimoto,Yasuo Imanishi,Takehisa Yamamoto,Geeta Hampson,Hiroyuki Koshiyama,Östen Ljunggren,Koichi Oba,In Myung Yang,Akimitsu Miyauchi,Michael J. Econs,Jeffrey R. Lavigne,Harald Jüppner,Harald Jüppner +16 more
TL;DR: FGF-23 is readily detectable in the plasma or serum of healthy persons and can be markedly elevated in those with oncogenic osteomalacia or X-linked hypophosphatemia, suggesting that this growth factor has a role in phosphate homeostasis.
References
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Journal ArticleDOI
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.
TL;DR: A new method for the identification of signal peptides and their cleavage sites based on neural networks trained on separate sets of prokaryotic and eukaryotic sequence that performs significantly better than previous prediction schemes and can easily be applied on genome-wide data sets.
SHORT COMMUNICATION Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
TL;DR: In this paper, a new method for the identification of in performance compared with the weight matrix method signal peptides and their cleavage sites based on neural (Arrigo et al., 1991; Ladunga et al, 1991; Schneider and networks trained on separate sets of prokaryotic and eukaryotic sequence.
Journal ArticleDOI
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer
TL;DR: The efficacy of this cDNA cloning strategy was demonstrated by isolating cDNA clones of mRNA from int-2, a mouse gene that expresses four different transcripts at low abundance, the longest of which is approximately 2.9 kilobases.
Book
The rat nervous system
TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.