Identification of an isozymic form of acetyl-CoA carboxylase.
Antonella Bianchi,Joseph L. Evans,A J Iverson,Ann-Charlotte Nordlund,Thomas D. Watts,Lee A. Witters +5 more
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TLDR
Its presence in rat cardiac and skeletal muscle, where fatty acid synthesis rates are low, suggest that it might play alternative roles in these tissues such as regulation of fatty acid oxidation or microsomal fatty acid elongation.About:
This article is published in Journal of Biological Chemistry.The article was published on 1990-01-25 and is currently open access. It has received 242 citations till now. The article focuses on the topics: Fatty acid elongation & Acetyl-CoA carboxylase.read more
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The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.
J. Denis McGarry,N. F. Brown +1 more
TL;DR: Key developments of the last 20 years that have led to the current understanding of the physiology of the CPT system, the structure of theCPT isoforms, the chromosomal localization of their respective genes, and the identification of mutations in the human population are reviewed.
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AMPK in Health and Disease
TL;DR: This review looks at how AMPK integrates stress responses such as exercise as well as nutrient and hormonal signals to control food intake, energy expenditure, and substrate utilization at the whole body level and the possible role of AMPK in multiple common diseases.
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The AMP‐Activated Protein Kinase
D. Grahame Hardie,David Carling +1 more
TL;DR: The central hypothesis is that the AMP-activated protein kinase cascade appears to be an ancient system which evolved to protect cells against the effects of nutritional or environmental stress, and protects the cell by switching off ATP-consuming pathways and switching on alternative pathways for ATP generation.
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Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.
TL;DR: The results raise the possibility that pharmacological manipulation of ACC2 may lead to loss of body fat in the context of normal caloric intake.
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Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
William W. Winder,D. G. Hardie +1 more
TL;DR: The activation of the AMP-activated protein kinase with consequent phosphorylation and inactivation of ACC may be one of the primary events in the control of malonyl-CoA and hence fatty acid oxidation during exercise.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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Regulation of hepatic fatty acid oxidation and ketone body production.
J. D. McGarry,Daniel W. Foster +1 more
TL;DR: The role of Exogenous Fatly Acids in the Control of Ketogenesis and Applications of the Model are examined.