Impairment and recovery of hand use after unilateral section of the dorsal columns of the spinal cord in squirrel monkeys
TLDR
It is suggested that cutaneous inputs from the hand and forelimb are critical to the integrity of functions such as reaching and grasping, and axon branches from peripheral afferents that terminate on neurons in the dorsal horn of the spinal cord are likely central to the functional recovery.About:
This article is published in Behavioural Brain Research.The article was published on 2013-09-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Spinal cord & Lesion.read more
Citations
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Journal ArticleDOI
Contribution of propriospinal neurons to recovery of hand dexterity after corticospinal tract lesions in monkeys.
Takamichi Tohyama,Takamichi Tohyama,Masaharu Kinoshita,Kenta Kobayashi,Kenta Kobayashi,Kaoru Isa,Dai Watanabe,Kazuto Kobayashi,Meigen Liu,Tadashi Isa,Tadashi Isa,Tadashi Isa +11 more
TL;DR: Double viral vectors are used to reversibly and selectively block the propriospinal neurons (PNs), one of the major intercalated neurons mediating cortical commands to motoneurons, in monkeys with partial spinal cord injury to provide evidence for causal contribution of PNs to recovery of hand dexterity after CST lesions.
Journal ArticleDOI
The reactivation of somatosensory cortex and behavioral recovery after sensory loss in mature primates.
TL;DR: It is concluded that preserved dorsal column afferents after nearly complete lesions contribute to the reactivation of cortex and the recovery of the behavior, but second-order sensory pathways in the spinal cord may also play an important role.
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Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury.
TL;DR: Midsagittal tissue bridges, detectable early after SCI, underwrite tract-specific electrophysiologic communication and are predictors of appropriate sensorimotor recovery.
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Biophysical and neural basis of resting state functional connectivity: Evidence from non-human primates
Li Min Chen,Li Min Chen,Pai Feng Yang,Pai Feng Yang,Feng Wang,Feng Wang,Arabinda Mishra,Arabinda Mishra,Zhaoyue Shi,Ruiqi Wu,Ruiqi Wu,Tung Lin Wu,George H. Wilson,George H. Wilson,Zhaohua Ding,John C. Gore,John C. Gore +16 more
TL;DR: Recent studies of rsFC within mesoscopic scale cortical networks within a well defined functional region of primary somatosensory cortex, as well as spinal cord and brain white matter in non-human primates, are summarized, demonstrating the valuable role of high field MRI and invasive measurements in an animal model to inform the interpretation of human imaging studies.
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Intracortical connections are altered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys.
TL;DR: Unexpectedly, the intrinsic connections within area 3b hand cortex were more widespread after incomplete dorsal column lesions (DCLs) than after a complete DCL, and these changes in connections may contribute to the reactivation process after injuries.
References
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New treatments in neurorehabilitation founded on basic research
TL;DR: Studies of phenomena such as cortical reorganization after a lesion, central nervous system repair, and the substantial enhancement of extremity use and linguistic function by behavioural therapy, support this emerging view.
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Impairments of reaching movements in patients without proprioception. I. Spatial errors.
TL;DR: The spatial errors in human patients with severe proprioceptive deficits resulting from large-fiber sensory neuropathy are characterized by using a task in which visual feedback of errors during movement was prevented and it was revealed that errors were associated with differences in velocity and acceleration for movements in different directions.
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Motor cortex reflexes associated with learned movement.
TL;DR: This finding supports the proposal that neurons of primate motor cortex may function in a transcortical servo-loop.
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Plasticity of primary somatosensory cortex paralleling sensorimotor skill recovery from stroke in adult monkeys.
TL;DR: Adult owl and squirrel monkeys were trained to master a small-object retrieval sensorimotor skill and revealed a postlesion reemergence of the representation of the fingertips engaged in the behavior in novel locations in two of five monkeys and a less substantial change in the representation in the hand in the intact parts of area 3b in three ofFive monkeys.