Improving the AJCC/TNM staging for adenocarcinomas of the appendix: the prognostic impact of histological grade.
Michael J. Overman,Keith Fournier,Chung Yuan Hu,Cathy Eng,Melissa W. Taggart,Richard E. Royal,Paul F. Mansfield,George J. Chang +7 more
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TLDR
The strong prognostic impact of histological grade for mucinous adenocarcinomas is primarily restricted to stage IV disease, and data do not support the combination of these 2 histological grades in the recent AJCC Staging Manual 7th edition.Abstract:
Purpose
Though histological grade is known to have a major prognostic impact in metastatic mucinous appendiceal adenocarcinomas; the prognostic impact of grade in localized disease, and the validity of the AJCC Cancer Staging Manual 7th edition decision to combine moderately and poorly differentiated mucinous adenocarcinomas into a single mucinous high-grade category, is not known.read more
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Journal ArticleDOI
The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: Analysis of the National Cancer Data Base
Elliot A. Asare,Elliot A. Asare,Carolyn C. Compton,Nader Hanna,Lauren Kosinski,Mary Kay Washington,Sanjay Kakar,Martin R. Weiser,Michael J. Overman +8 more
TL;DR: The authors sought to explore the interplay of these factors with systemic chemotherapy in a large population data set and found that mucinous histology, histologic grade, and stage are important factors in the development of Adenocarcinomas of the appendix.
Journal ArticleDOI
Appendiceal Mucinous Neoplasms: Diagnosis and Management
Walid L. Shaib,Rita Assi,Ali Shamseddine,Olatunji B. Alese,Charles A. Staley,Bahar Memis,Volkan Adsay,Tonios Bekaii‐Saab,Bassel F. El-Rayes +8 more
TL;DR: This review summarizes all AMN classifications and proposes a treatment algorithm based on stage and histology of disease, a reference to guide gastroenterologists, pathologists, surgeons, and oncologists in the management of appendiceal mucinous neoplasms.
Journal ArticleDOI
Neoplasms of the Appendix: Pictorial Review with Clinical and Pathologic Correlation
Laura M Leonards,Anokh Pahwa,Maitraya K. Patel,Jeffrey Petersen,Michael J Nguyen,Cecilia M. Jude +5 more
TL;DR: Novel treatments such as hyperthermic intraperitoneal chemotherapy have increased survival for patients with mucinous tumors, and detailed description of organ, nodal, and peritoneal involvement informs surgical management with the goal of complete cytoreduction is provided.
Journal ArticleDOI
An Update on the Diagnosis, Grading, and Staging of Appendiceal Mucinous Neoplasms
Mark A. Valasek,Reetesh K. Pai +1 more
TL;DR: An update on the various classification systems that have been recently proposed for appendiceal mucinous neoplasia, with a particular emphasis on how to handle and report the histologic findings for these tumors using the newly published Peritoneal Surface Oncology Group International (PSOGI) and American Joint Committee on Cancer (AJCC) eighth edition guidelines.
Journal ArticleDOI
The American Society of Colon and Rectal Surgeons, Clinical Practice Guidelines for the Management of Appendiceal Neoplasms.
Sean C. Glasgow,Wolfgang B. Gaertner,David B. Stewart,Jennifer S. Davids,Karim Alavi,Ian M. Paquette,Scott R. Steele,Daniel L. Feingold +7 more
TL;DR: These guidelines are intended for the use of all practitioners, healthcare workers, and patients who desire information about the management of the conditions addressed by the topics covered in these guidelines.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Journal ArticleDOI
Regression models for relative survival.
TL;DR: The model can be estimated in any software package that estimates GLMs with user‐defined link functions and utilizes the theory of generalized linear models for assessing goodness‐of‐fit and studying regression diagnostics.
Journal ArticleDOI
Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. A clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to "pseudomyxoma peritonei".
Brigite M. Ronnett,Christopher M Zahn,Robert J. Kurman,Mary E. Kass,Paul H. Sugarbaker,Barry M. Shmookler +5 more
TL;DR: The term DPAM should be used to diagnose the histologically benign peritoneal lesions associated with ruptured appendiceal mucinous adenomas and those that are pathologically identical but lack a demonstrable appendicesal adenoma, which should be designated PMCA because they have recognizably different pathologic features and a significantly worse prognosis.
Journal ArticleDOI
Results of treatment of 385 patients with peritoneal surface spread of appendiceal malignancy.
TL;DR: Cytoreductive surgery and perioperative intraperitoneal chemotherapy can be used to salvage selected patients with peritoneal surface spread of appendiceal primary tumors.
Journal ArticleDOI
Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998.
TL;DR: Cancer of the appendix is an uncommon disease that is rarely suspected rarely before surgery, and although several case series of these tumors have been published, little research has been anchored in population‐based data on cancer of the Appendix.
Related Papers (5)
Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998.
Early- and Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Treated by a Strategy of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Terence C. Chua,B. J. Moran,Paul H. Sugarbaker,Edward A. Levine,Olivier Glehen,François Noël Gilly,Dario Baratti,Marcello Deraco,Dominique Elias,Armando Sardi,Winston Liauw,Tristan D. Yan,P. Barrios,Alberto Gomez Portilla,Ignace H J T de Hingh,Wim Ceelen,Joerg O.W. Pelz,Pompiliu Piso,Santiago González-Moreno,Kurt Van der Speeten,David L. Morris +20 more