Journal ArticleDOI
In-vitro and in-vivo study of indomethacin loaded gelatin nanoparticles.
TLDR
A good in vitro-in vivo correlation established the formulation of indomethacin loaded gelatin nanoparticles prepared by double desolvation method for controlled drug delivery and showed significant enhancement of various pharmacokinetic parameters.Abstract:
The present research work deals with fabrication of indomethacin loaded gelatin nanoparticles prepared by double desolvation method for controlled drug delivery. Submicron polymeric particles with size 20% in 1 hr) followed by controlled release (> 75% in 12 hr). Among the kinetic models employed, the Higuchi model showed a better fit (R2 > 0.9) with n < 0.43 (Peppas model) indicating a Fickian type of release pattern. The batch 2GA was optimum in terms of size, entrapment efficiency and drug release. Anti-inflammatory activity of the drug loaded nanoparticles (IGNP) and pure drug solution (IDM) was studied by rat paw model and IGNP significantly (P < or = 0.001) decreased the paw volume as compared to IDM. Pharmacokinetic study showed significant enhancement (P < 0.001) of various pharmacokinetic parameters. The observed t(max) value was 3 h for IGNP compared to 1 h for IDM. Cmax of IGNP had higher value (110.81 +/- 8.53 microg/mL) compared to that of IDM (51.66 +/- 7.5 microg/mL). AUC0-12 was 1009.78 +/- 80.24 and 194.33 +/- 46.76/microg x h/mL in IGNP and IDM respectively (relative bioavailability 500%). Further, a good in vitro-in vivo correlation established the formulation for future trials.read more
Citations
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Protein-based nanocarriers as promising drug and gene delivery systems
TL;DR: The current review highlights the main advances achieved in utilizing protein nanocarriers as natural vehicles for drug and gene delivery tasks with respect to types, advantages, limitations, formulation aspects as well as the major outcomes of the in vitro and in vivo investigations.
Journal ArticleDOI
Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research.
TL;DR: A general review of the different preparation techniques of gelatin nanoparticles (GNPs): desolvation, coacervation-phase separation, emulsification-solvent evaporation, reverse phase microemulsion, nanoprecipitation, self-assembly and layer-by-layer coating, from the point of view of the methodological and mechanistic aspects involved.
Journal ArticleDOI
A Review of In Vitro Drug Release Test Methods for Nano-Sized Dosage Forms
TL;DR: This review summarizes the methods used to study real-time (37°C) drug release from nanoparticulate drug delivery systems and establish an IVIVC, describing the principle of each method along with their advantages and disadvantages, including challenges with set-up and sampling.
Journal ArticleDOI
Gelatin carriers for drug and cell delivery in tissue engineering
TL;DR: G gelatin modifications for immune system evasion, drug stabilization, and targeted delivery, as well as gelatin composite systems based on ceramics, naturally-occurring polymers, and synthetic polymers are discussed.
Journal ArticleDOI
Drug delivery from gelatin-based systems
Maytal Foox,Meital Zilberman +1 more
TL;DR: The modification of gelatin and its combinations with other biomaterials have demonstrated the flexibility of these systems and can be employed for meeting the challenges of finding ideal carrier systems that enable specific, targeted and controlled release in response to demands in the body.
References
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Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
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A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
TL;DR: In this paper, a simple exponential relation Mt/M∞ = ktn is introduced to describe the general solute release behavior of controlled release polymeric devices, where Mt is the fractional release, t is the release time, k is a constant, and n is the diffusional exponent characteristic of the release mechanism.
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Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
TL;DR: In this review the most important preparation methods are described, especially those that make use of natural polymers, andvantages and disadvantages will be presented so as to facilitate selection of an appropriate nanoencapsulation method according to a particular application.
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Control of encapsulation efficiency and initial burst in polymeric microparticle systems
Yoon Yeo,Kinam Park +1 more
TL;DR: A literature review of the formulation parameters that are known to influence encapsulation efficiency and initial burst in the emulsion-solvent evaporation/extraction method is provided.
Journal ArticleDOI
Polymeric nanoparticulate system: a potential approach for ocular drug delivery.
TL;DR: DNPs have been shown to be amenable to targeting of the drug to the site of action, leading to a decreases in the dose required and a decrease in side effects, which makes them a novel polymeric drug delivery device, which fulfils the requirements for ophthalmic application.