Open AccessJournal Article
In vitro assay of alpha amylase inhibitory activity of some indigenous plants
Mangesh A. Bhutkar,S.B. Bhise +1 more
TLDR
Aqueous extracts from leaves, stems, seeds and roots of selected plants namely Tamarindus indica, Catharanthus roseus and Caesalpinia bonducella which are used in the Ayurvedic traditional system of medicine to treat diabetes were tested for their inhibitory effect on α-amylase.Abstract:
Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and its type II is the major form of diabetes, accounting for 90% of cases worldwide. The management of the blood glucose level is a critical strategy in the control of diabetes complications. There are many and diverse therapeutic strategies in the management of Type II diabetes. The inhibition of carbohydrate hydrolyzing enzymes such as α-amylase can be an important strategy to lower postprandial blood glucose levels. Such inhibitors which find application in the clinical practice for management of diabetes are known to be associated with various gastrointestinal side effects. Therefore, it is the need of time to identify and explore the amylase inhibitors from natural sources having fewer side effects. In the present study, aqueous extracts from leaves, stems, seeds and roots of selected plants namely Tamarindus indica, Catharanthus roseus and Caesalpinia bonducella which are used in the Ayurvedic traditional system of medicine to treat diabetes were tested for their inhibitory effect on α-amylase. The results revealed that aqueous extracts of leaves of T.indica 9 mg/mL, extracts from the stems and roots of C. roseus and C. bonducella (9 mg/mL) exhibited significant (more than 70%) reduction in amylase activity. The highest inhibition i.e. 87.26% was observed at a concentration of 9mg/mL with the aqueous extract of seeds of C. bonducella.read more
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Antidiabetic Potential of Medicinal Plants and Their Active Components.
Bahare Salehi,Athar Ata,Nanjangud V. Anil Kumar,Farukh Sharopov,Karina Ramírez-Alarcón,Ana M. Ruiz-Ortega,Seyed Abdulmajid Ayatollahi,Patrick Valere Tsouh Fokou,Farzad Kobarfard,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Marcello Iriti,Yasaman Taheri,Miquel Martorell,Antoni Sureda,William N. Setzer,Alessandra Durazzo,Massimo Lucarini,Antonello Santini,Raffaele Capasso,Elise Adrian Ostrander,Atta-ur-Rahman,Muhammad Iqbal Choudhary,William C. Cho,Javad Sharifi-Rad +24 more
TL;DR: Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies.
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References
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Journal ArticleDOI
Alpha-glucosidase inhibitors
TL;DR: Alpha-glucosidase inhibitors are antihyperglycemic agents that lower blood glucose by delaying the digestion and absorption of complex carbohydrates by competitive inhibitors of the enzymes in the brush border of enterocytes that cleave eligosaccharides to monosACcharides.