Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints
Daniel Prieto-Alhambra,Andrew Judge,Muhammad Javaid,Cyrus Cooper,Adolfo Diez-Perez,Nigel K Arden +5 more
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TLDR
The effect of age is greatest in the elderly for knee and hip OA, but around the menopause for hand OA; OA clusters within individuals, with higher risk of incident knee and Hip disease from prevalent lower limb andHand OA.Abstract:
Objectives Data on the incidence of symptomatic osteoarthritis (OA) are scarce. We estimated incidence of clinical hip, knee and hand OA, and studied the effect of prevalent OA on joint-specific incident OA. Methods SIDIAP contains primary care records for>5 million people from Catalonia (Spain). Participants aged ≥40 years with an incident diagnosis of knee, hip or hand OA between 2006 and 2010 were identified using International Classification of Diseases (ICD)-10 codes. Incidence rates and female-to-male rate ratios (RRs) for each joint site were calculated. Age, gender and body mass index-adjusted HR for future joint-specific OA according to prevalent OA at other sites were estimated using Cox regression. Results 3 266 826 participants were studied for a median of 4.45 years. Knee and hip OA rates increased continuously with age, and female-to-male RRs were highest at age 70–75 years. In contrast, female hand OA risk peaked at age 60–64 years, and corresponding female-to-male RR was highest at age 50–55 years. Adjusted HR for prevalent knee OA on risk of hip OA was 1.35 (99% CI 1.28 to 1.43); prevalent hip OA on incident knee OA: HR 1.15 (1.08 to 1.23). Prevalent hand OA predicted incident knee and hip OA: HR 1.20 (1.14 to 1.26) and 1.23 (1.13 to 1.34), respectively. Conclusions The effect of age is greatest in the elderly for knee and hip OA, but around the menopause for hand OA. OA clusters within individuals, with higher risk of incident knee and hip disease from prevalent lower limb and hand OA.read more
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Global, regional and national burden of osteoarthritis 1990-2017: A systematic analysis of the Global Burden of Disease Study 2017
Saeid Safiri,Ali-Asghar Kolahi,Damian G Hoy,Emma Smith,Deepti Bettampadi,Mohammad Ali Mansournia,Amir Almasi-Hashiani,Ahad Ashrafi-Asgarabad,Maziar Moradi-Lakeh,Mostafa Qorbani,Gary S. Collins,Anthony D. Woolf,Lyn March,Marita Cross +13 more
TL;DR: The global prevalence was higher in women and increased with age, peaking at the >95 age group among women and men in 2017, and a positive association was found between the age-standardised YLD rate and SDI at the regional and national levels.
Journal ArticleDOI
Ageing and the pathogenesis of osteoarthritis
TL;DR: Improved understanding of ageing-related mechanisms that promote OA could lead to the discovery of new targets for therapies that aim to slow or stop the progression of this chronic and disabling condition.
Journal ArticleDOI
Risk factors and burden of osteoarthritis.
Clémence Palazzo,Christelle Nguyen,Marie-Martine Lefèvre-Colau,François Rannou,Serge Poiraudeau +4 more
TL;DR: Patients with OA are at greater risk of all-cause mortality, particularly for cardiovascular diseases, than the general population, and excess mortality is closely associated with disability level, so strategies to reduce burden through primary and secondary prevention programs are increasingly important.
Journal ArticleDOI
Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies
TL;DR: The global prevalence and incidence of knee OA varied substantially between individual countries and increased with age, and these findings can be used to better assess the global health burden of knees OA.
Journal ArticleDOI
State of the evidence.
TL;DR: Osteoarthritis is a complex, multifactorial disease, and there is still much to learn regarding mechanisms underlying incidence and progression, however, there are several known modifiable and preventable risk factors, including obesity and joint injury; efforts to mitigate these risks can help to lessen the impact of osteoarth arthritis.
References
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Roy D. Altman,Graciela S. Alarcón,D. Appelrouth,Daniel Bloch,David G. Borenstein,Kenneth D. Brandt,C. Brown,Cooke Td,W W Daniel,D. Feldman,Robert A. Greenwald,Marc C. Hochberg,David S. Howell,Robert W. Ike,P. Kapila,David L. Kaplan,William J. Koopman,Catherine Marino,Eric V. McDonald,Dennis J. McShane,Thomas A. Medsger,B. A. Michel,William A. Murphy,T. Osial,Rosalind Ramsey-Goldman,Bruce M. Rothschild,Frederick Wolfe +26 more
TL;DR: Clinical criteria for the classification of symptomatic idiopathic (primary) osteoarthritis of the hands were developed from data collected in a multicenter study and required that at least 3 of these 4 criteria be present to classify a patient as having OA of the hand.
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Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care
TL;DR: Knee osteoarthritis sufficiently severe to consider joint replacement represents a minority of all knee pain and disability suffered by older people and healthcare provision in primary care needs to focus on this broader group to impact on community levels of pain and Disability.
Journal ArticleDOI
A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
Velandai Srikanth,Jayne L. Fryer,Guangju Zhai,Tania Winzenberg,David W. Hosmer,David W. Hosmer,Graeme Jones +6 more
TL;DR: The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk and females also tend to have more severe knee OA, particularly after menopausal age.
Journal ArticleDOI
Lifetime risk of symptomatic knee osteoarthritis
Louise B. Murphy,Todd A. Schwartz,Charles G. Helmick,Jordan B. Renner,Gail Tudor,Gary G. Koch,Anca D. Dragomir,William D. Kalsbeek,Gheorghe Luta,Joanne M. Jordan +9 more
TL;DR: Nearly half of the adults in Johnston County will develop symptomatic knee OA by age 85 years, with lifetime risk highest among obese persons, which underscores the immediate need for greater use of clinical and public health interventions, especially those that address weight loss and self-management.
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Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization.
TL;DR: The incidence of symptomatic hand, hip, and knee OA increased with age, and women had higher rates than men, especially after age 50, and a leveling off or decline occurred for both groups around the age of 80.
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