Journal ArticleDOI
Incidence of very mild to severe dementia and Alzheimer's disease in Denmark: the Odense Study.
Kjeld Andersen,Helle Hvilsted Nielsen,A. Lolk,John Sahl Andersen,I. Becker,Per Kragh-Sørensen +5 more
TLDR
In this article, an individualized cutoff for the screening instrument resulted in detection of a substantial number of cases with very mild dementia, which subsequently resulted in higher incidence rates than those reported in most other studies.Abstract:
Objective: Calculation of incidence of dementia and AD, including cases in the earliest phases of the diseases. Background: Establishment of incidence estimates is important for the future planning of the health care system, and incidence studies can offer insights into risk factors. Methods: A total of 5,237 persons age 65 to 84 years were randomly drawn among people living in the municipality of Odense, Denmark. Of this sample 3,086 persons were eligible for the incidence study. All participants were examined with CAMCOG, the cognitive section of The Cambridge Examination for Mental Disorders of the Elderly (CAMDEX), and the follow-up period was 2 years. Using multiple linear regression, the CAMCOG cutoff score was individualized to detect even minor cognitive decline with optimal precision. Possibly demented persons were further examined with the remaining part of the CAMDEX and neuropsychological tests. AD was diagnosed according to National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association criteria for probable AD, and vascular dementia and dementia of other types were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised) criteria for dementia. Finally, the severity of dementia was determined according to the Clinical Dementia Rating scale. Results: The incidence rate for very mild to severe dementia was 29.5 per 1,000 person-years and 20.9 for AD, and the rates were similar for men and women. Conclusion: Application of an individualized cutoff for the screening instrument resulted in detection of a substantial number of cases with very mild dementia, which subsequently resulted in higher incidence rates than those reported in most other studies.read more
Citations
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Journal ArticleDOI
Epidemiology of Alzheimer Disease
Richard Mayeux,Yaakov Stern +1 more
TL;DR: The prevalence and incidence rates, the established environmental risk factors, and the protective factors are discussed, and genetic variants predisposing to disease are reviewed.
Journal ArticleDOI
Conversion from subtypes of mild cognitive impairment to Alzheimer dementia
Peter Fischer,Susanne Jungwirth,Sonja Zehetmayer,Silvia Weissgram,Selma Hoenigschnabl,Ellen Gelpi,Wolfgang Krampla,K. H. Tragl +7 more
TL;DR: Patients with mild cognitive impairment (MCI) showed a high probability to be diagnosed with Alzheimer dementia (AD) after 30 months, and subtypes of MCI were not useful in defining early stages of various types of dementia.
Journal ArticleDOI
A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies
TL;DR: Multivariable methods of analyzing attrition in longitudinal studies show consistent patterns of dropout between differing studies, with a small number of key relationships.
Journal ArticleDOI
Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia
Christian Kronborg Andersen,Kim U Wittrup-Jensen,Anette Lolk,Kjeld Andersen,Per Kragh-Sørensen +4 more
TL;DR: Dependency upon others to perform ADL was the main factor affecting HRQoL, and Danish EQ-5D social tariffs were used to value patients' HRQol.
Journal ArticleDOI
Current Epidemiology of Mild Cognitive Impairment and Other Predementia Syndromes
Francesco Panza,Alessia D'Introno,Anna M. Colacicco,Cristiano Capurso,Angelo Del Parigi,Richard J. Caselli,Alberto Pilotto,Giovanni Argentieri,Pier Luigi Scapicchio,Emanuele Scafato,Antonio Capurso,Vincenzo Solfrizzi +11 more
TL;DR: This review summarizes existing epidemiological studies of the defined clinical predementia syndromes and their progression to dementia and concludes that Mild Cognitive Impairment definition is less consistent in population-based studies than clinical studies, in which progression to AD is also more consistent.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia.
TL;DR: A new interview schedule for the diagnosis and measurement of dementia in the elderly is described and is acceptable to patients, has a high inter-rater reliability and the cognitive section has been shown to have high and specificity.
Journal ArticleDOI
15-year longitudinal study of blood pressure and dementia
Ingmar Skoog,Lars Nilsson,G. Persson,Bodil Lernfelt,Sten Landahl,Bo Palmertz,L-A Andreasson,Anders Odén,Alvar Svanborg +8 more
TL;DR: Previously increased blood pressure may increase the risk for dementia by inducing small-vessel disease and white-matter lesions, but to what extent the decline in blood pressure before dementia onset is a consequence or a cause of the brain disease remains to be elucidated.
Journal ArticleDOI
Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study.
Albert Hofman,Alewijn Ott,Monique M.B. Breteler,Michiel L. Bots,Arjen J .C. Slooter,Frans van Harskamp,Cornelia van Duijn,Christine Van Broeckhoven,Diederick E. Grobbee +8 more
TL;DR: It is suggested that dementia and its two major subtypes Alzheimer's disease and vascular dementia are associated with atherosclerosis and that there is an interaction between apolipoprotein E and Atherosclerosis in the aetiology of Alzheimer’s disease.
Journal ArticleDOI
On the methods and theory of reliability.
TL;DR: This paper reviews the most frequently used and misused reliability measures appearing in the mental health literature and suggests some suitable reliability measures to be used.