Increasing circulating sphingosine-1-phosphate attenuates lung injury during ex vivo lung perfusion
J. Hunter Mehaffey,Eric J. Charles,Adishesh K. Narahari,Sarah A. Schubert,Victor E. Laubach,Nicholas R. Teman,Kevin R. Lynch,Irving L. Kron,Ashish Sharma +8 more
TLDR
Elevation of circulating sphingosine‐1‐phosphate via specific pharmacologic modalities during ex vivo lung perfusion may provide endothelial protection in marginal donor lungs leading to successful lung rehabilitation for transplantation.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 2018-08-01 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Lung injury & Pulmonary compliance.read more
Citations
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Review of Current Machine Perfusion Therapeutics for Organ Preservation.
TL;DR: Ex situ machine perfusion (MP), compared with the traditional static cold storage, may better protect marginal organs from ischemia-reperfusion injury and act as a platform for dynamic administration of pharmacological agents or gene therapy to further improve transplant outcomes.
Journal ArticleDOI
Total parenteral nutrition in ex vivo lung perfusion: Addressing metabolism improves both inflammation and oxygenation.
TL;DR: The addition of total parenteral nutrition in EVLP allows for better electrolyte composition, decreased inflammation, and improved graft performance, as well as a shift toward proteolysis for energy substrate.
Journal ArticleDOI
The role of sphingosine kinase 2 in alcoholic liver disease.
Eric K. Kwong,Runping Liu,Derrick Zhao,Xiaojiaoyang Li,Weiwei Zhu,Xuan Wang,Emily C. Gurley,Guanhua Lai,Jimin Liu,Phillip B. Hylemon,Huiping Zhou +10 more
TL;DR: It is demonstrated that compared to wild-type mice, SphK2 deficient (SphK2-/-) mice exhibited a greater degree of liver injury and hepatic lipid accumulation after feeding with an alcohol diet for 60 days, and modulating the SphK 2-mediated signaling pathway may represent a novel therapeutic strategy for the treatment of ALD and other metabolic liver diseases.
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Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice
TL;DR: In this paper, the authors explored whether sphingosine kinase 1 (SphK1)/sphingosinesine-1-phosphate (S1P)/s1P/S1PR1) signaling pathway functions in lung injury caused by acute ethanol intoxication-enhanced sepsis, as well as its underlying mechanism.
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Review 2: Primary graft dysfunction after lung transplant-pathophysiology, clinical considerations and therapeutic targets.
TL;DR: The pathophysiology, clinical management and potential therapeutic targets of PGD are discussed and several promising experimental therapeutic targets are identified.
References
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Journal ArticleDOI
Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult lung and heart-lung transplant report--2005.
Jason D. Christie,Leah B. Edwards,Anna Y. Kucheryavaya,Paul Aurora,Fabienne Dobbels,Richard Kirk,Axel O. Rahmel,Josef Stehlik,Marshall I. Hertz +8 more
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Technique for prolonged normothermic ex vivo lung perfusion.
Marcelo Cypel,Jonathan C. Yeung,S. Hirayama,M. Rubacha,Stefan Fischer,Masaki Anraku,Masaaki Sato,Stephen Harwood,Andrew Pierre,Thomas K. Waddell,Marc de Perrot,Mingyao Liu,Shaf Keshavjee +12 more
TL;DR: Twelve hours of EVLP at physiologic temperatures using an acellular perfusate is achievable and maintains the donor lungs without inflicting significant added injury and can be used to assess, maintain and treat injured donor lungs.
Journal ArticleDOI
Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation
Robert C. King,Oliver A.R. Binns,Filiberto Rodriguez,R.Chai Kanithanon,Thomas M. Daniel,William D. Spotnitz,Curtis G. Tribble,Irving L. Kron +7 more
TL;DR: Clinical impact of reperfusion injury in lung transplant recipients from June 1990 until June 1998 increased in-hospital mortality and morbidity resulting in prolonged ventilation, length of stay in the intensive care unit, and cost of hospitalization.
Journal ArticleDOI
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney
Alaa S. Awad,Hong Ye,Liping Huang,Li Li,Frank W. Foss,Timothy L. Macdonald,Kevin R. Lynch,Mark D. Okusa +7 more
TL;DR: The mechanisms involved in renal ischemia-reperfusion injury (IRI) are complex and appear to involve the early participation of bone marrow-derived cells and T lymphocytes participate in the pathogenesis of IRI.
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Identification of a molecular target of psychosine and its role in globoid cell formation.
TL;DR: The discovery of a molecular target for psychosine suggests a mechanism for the globoid cell histology characteristic of GLD, provides a tool with which to explore the disjunction of mitosis and cytokinesis in cell cultures, and provides a platform for developing a medicinal chemistry for Psychosine.
Related Papers (5)
Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation
Marcelo Cypel,Jonathan C. Yeung,Mingyao Liu,Masaki Anraku,Fengshi Chen,W. Karolak,Masaaki Sato,Jane Laratta,Sassan Azad,Mindy Madonik,Chung-Wai Chow,Cecilia Chaparro,Michael Hutcheon,Lianne G. Singer,Arthur S. Slutsky,Kazuhiro Yasufuku,Marc de Perrot,Andrew Pierre,Thomas K. Waddell,Shaf Keshavjee +19 more