Journal ArticleDOI
Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?
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TLDR
New evidence is presented to indicate a determining role for the 'natural' immune response, including NK cells and cells of the mast cell/basophil lineage, in the subsequent 'specific' T-cell response.About:
This article is published in Immunology Today.The article was published on 1992-01-01. It has received 821 citations till now. The article focuses on the topics: Lymphokine & Antigen.read more
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Innate Immunity: The Virtues of a Nonclonal System of Recognition
TL;DR: Characterization of the nonclonal receptors of the innate immune system responsible for the adjuvant activity, and, evidently, for the associated side effects, would provide a powerful alternative approach, which would ultimately allow one to target these receptors directly.
Journal ArticleDOI
The instructive role of innate immunity in the acquired immune response.
TL;DR: Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops but may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response.
Journal ArticleDOI
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
Roberto Manetti,Paola Parronchi,Maria Grazia Giudizi,Marie-Pierre Piccinni,Enrico Maggi,Giorgio Trinchieri,Sergio Romagnani +6 more
TL;DR: IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses.
Journal ArticleDOI
Innate immunity: impact on the adaptive immune response
TL;DR: The intent in this review is to point out the similarities and differences in these two types of host response to infection, and to indicate the present level of understanding of how these can be integrated into a more complete description of the immune response.
Journal ArticleDOI
MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
TL;DR: The specificity and function of mouse NK1 T cells are reviewed, the relationship of this lineage to mainstream T cells and NK cells is discussed, and the novel regulatory pathway, which straddles the innate and the adaptive immune systems, is discussed.
References
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Journal Article
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
TL;DR: A panel of antigen-specific mouse helper T cell clones was characterized according to patterns of lymphokine activity production, and two types of T cell were distinguished.
Journal ArticleDOI
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.
M Kobayashi,Lori Fitz,M Ryan,Rodney M. Hewick,Steven C. Clark,S Chan,R Loudon,F Sherman,B Perussia,Giorgio Trinchieri +9 more
TL;DR: Data strongly suggest that the same molecule mediates these three activities, although the presence of traces of contaminant peptides even in the most purified NKSF preparations does not allow us to exclude the possibility that distinct biologically active molecules have been co-purified.
Journal ArticleDOI
Human TH1 and TH2 subsets: doubt no more
TL;DR: It appears that key functional events are emerging in the pathogenesis of HIV-1 infection leading to AIDS and that monitoring of these events is practical; there is a sense of urgency about these studies: they hold clues for the diagnosis, prevention and therapy of AIDS.
Journal ArticleDOI
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.
TL;DR: In this article, the authors found that T cells from anti-IgD-injected mice produce very small amounts of interleukin 4 (IL-4) in response to stimulation on anti-CD3-coated dishes.
Journal Article
Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients
Eddy A. Wierenga,Mieke Snoek,C.H. de Groot,I Chrétien,Jan D. Bos,Henk M. Jansen,Martien L. Kapsenberg +6 more
TL;DR: It is suggested that CD4+ T lymphocytes that produce IL-4, but not IFN-gamma, occur in high frequencies in the allergen-specific T cell repertoires of atopic donors, which may have important implications for the pathomechanism of atopy disease.
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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more