Inflammation is an Independent Risk Factor for Colonic Neoplasia in Patients with Ulcerative Colitis: a Case–Control Study
David T. Rubin,Dezheng Huo,Jami Kinnucan,Mina S. Sedrak,Nicole E. McCullom,Alana P. Bunnag,Elin P. Raun-Royer,Russell D. Cohen,Stephen B. Hanauer,John Hart,Jerrold R. Turner +10 more
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TLDR
In a case-control study, increased inflammation is associated with CRN in patients with UC and use of immune modulators reduced the risk for CRN, indicating that these drugs have chemoprotective effects.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-12-01 and is currently open access. It has received 233 citations till now. The article focuses on the topics: Primary sclerosing cholangitis & Inflammatory bowel disease.read more
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شاخصهای نمرهدهی بافتشناختی برای ارزیابی فعالیت بیماری در کولیت اولسراتیو
Mahmoud Mosli,Claire E Parker,Sigrid Nelson,Kenneth A. Baker,John K MacDonald,Guangyong Zou,Brian G. Feagan,Reena Khanna,Barrett G. Levesque,Vipul Jairath +9 more
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ECCO Topical Review Optimising Reporting in Surgery, Endoscopy, and Histopathology.
Michel Adamina,Michel Adamina,Roger Feakins,Marietta Iacucci,Antonino Spinelli,Rosanna Cannatelli,André D'Hoore,Ann Driessen,Konstantinos H. Katsanos,Aart Mookhoek,Pär Myrelid,Gianluca Pellino,Gianluca Pellino,Georgios Peros,Gian Eugenio Tontini,Gian Eugenio Tontini,Monika Tripathi,Henit Yanai,Magali Svrcek +18 more
TL;DR: In this article, a consensus expert panel consisting of gastroenterologists, surgeons, and pathologists, convened by the European Crohn's and Colitis Organisation, performed a systematic literature review.
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Clinical Aspects of Idiopathic Inflammatory Bowel Disease: A Review for Pathologists
TL;DR: Having this team approach improves understanding of the pertinent clinical and surgical aspects of the disease and assists in the recognition of unusual presentation of variants, as well as mimics of idiopathic inflammatory bowel disease, by pathologists.
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Predicting Colorectal Cancer Occurrence in IBD.
TL;DR: A review summarises the known risk factors associated with colitis-associated colorectal cancer and explores the molecular landscape that has the potential to complement and optimise the existing IBD surveillance program.
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Relationship between endoscopic mucosal healing and histologic inflammation during remission maintenance phase in ulcerative colitis: a retrospective study.
Mimari Kanazawa,Fumiaki Takahashi,Keiichi Tominaga,Keiichiro Abe,Naoya Izawa,Koh Fukushi,Kazunori Nagashima,Akira Kanamori,Kazuhiro Takenaka,Takeshi Sugaya,Makoto Iijima,Atsuko Takada,Yasuo Imai,Hideyuki Hiraishi,Atsushi Irisawa +14 more
TL;DR: This retrospective study suggests that histological healing can be a predictor of sustained remission in UC patients, and examination of histological inflammation provides useful information for long-term management of UC, particularly in patients with MES 1.
References
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TL;DR: A general statistical methodology for the analysis of multivariate categorical data arising from observer reliability studies is presented and tests for interobserver bias are presented in terms of first-order marginal homogeneity and measures of interob server agreement are developed as generalized kappa-type statistics.
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The risk of colorectal cancer in ulcerative colitis: a meta-analysis
TL;DR: Using new meta-analysis techniques, the risk of CRC in UC by decade of disease and defined the risk in pancolitics and children was determined and how risk varies with geography was estimated.
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Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
Steven H. Itzkowitz,Xianyang Yio +1 more
TL;DR: Observations of mice genetically prone to inflammatory bowel disease also develop colorectal cancer especially in the presence of bacterial colonization offer compelling support for the role of inflammation in colon carcinogenesis.
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Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis
Matthew D. Rutter,Brian Saunders,Kay H. Wilkinson,Steve Rumbles,Gillian Schofield,Michael A. Kamm,Christopher S. Williams,Ashley B. Price,Ian C. Talbot,Alastair Forbes +9 more
TL;DR: In long-standing extensive ulcerative colitis, the severity of colonic inflammation is an important determinant of the risk of colorectal neoplasia and endoscopic and histological grading of inflammation could allow better risk stratification for surveillance programs.