Inflammation is an Independent Risk Factor for Colonic Neoplasia in Patients with Ulcerative Colitis: a Case–Control Study
David T. Rubin,Dezheng Huo,Jami Kinnucan,Mina S. Sedrak,Nicole E. McCullom,Alana P. Bunnag,Elin P. Raun-Royer,Russell D. Cohen,Stephen B. Hanauer,John Hart,Jerrold R. Turner +10 more
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TLDR
In a case-control study, increased inflammation is associated with CRN in patients with UC and use of immune modulators reduced the risk for CRN, indicating that these drugs have chemoprotective effects.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-12-01 and is currently open access. It has received 233 citations till now. The article focuses on the topics: Primary sclerosing cholangitis & Inflammatory bowel disease.read more
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The epidemiology of inflammatory bowel disease.
Johan Burisch,Pia Munkholm +1 more
TL;DR: In recent years, self-management and patient empowerment, combined with evolving eHealth solutions, has utilized epidemiological knowledge on disease patterns and has been improving compliance and the timing of adjusting therapies, thus optimizing efficacy by individualizing medication in the community setting.
Journal ArticleDOI
The role of endoscopy in inflammatory bowel disease.
Amandeep K. Shergill,Jenifer R. Lightdale,David H. Bruining,Ruben D. Acosta,Vinay Chandrasekhara,Krishnavel V. Chathadi,G. Anton Decker,Dayna S. Early,John A. Evans,Robert D. Fanelli,Deborah A. Fisher,Lisa Fonkalsrud,Kimberly Foley,Joo Ha Hwang,Terry L. Jue,Mouen A. Khashab,V. Raman Muthusamy,Shabana F. Pasha,John R. Saltzman,Ravi Sharaf,Brooks D. Cash,John M. DeWitt +21 more
TL;DR: Preliminary data suggest that mucosal healing assessed with endoscopy after biologic treatments could be associated with a better prognosis, and some operative techniques like balloon dilation could possibly be employed more frequently in the future in the management of Crohn's disease.
Journal ArticleDOI
Mucosal Healing Is Associated With Improved Long-term Outcomes of Patients With Ulcerative Colitis: A Systematic Review and Meta-analysis.
TL;DR: In a meta-analysis, MH is associated with long-term clinical remission, avoidance of colectomy, and corticosteroid-free clinical remission and is therefore appropriate goal of UC therapy.
Journal Article
The role of endoscopy in inflammatory bowel disease.
Marco Daperno,Raffaello Sostegni,Alessandro Lavagna,L. Crocellà,Elena Ercole,C. Rigazio,Rodolfo Rocca,Angelo Pera +7 more
TL;DR: In this paper, the authors proposed that coloscopy is an essential tool for diagnosis, management and prognostic evaluation of inflammatory bowel disease, and that colonoscopy performed by an expert endoscopist allows accurate diagnosis of Crohn's disease or ulcerative colitis in up to 90% of cases.
Journal ArticleDOI
Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis
Nadia Mohammed Vashist,Mark A Samaan,Mahmoud Mosli,Claire E Parker,John K MacDonald,John K MacDonald,Sigrid Nelson,Guangyong Zou,Guangyong Zou,Brian G. Feagan,Brian G. Feagan,Reena Khanna,Vipul Jairath +12 more
TL;DR: A systematic review was undertaken to identify and evaluate the development and operating characteristics of histologic disease activity indices used to assess disease activity in people with ulcerative colitis and found the Nancy Index and the Robarts Histopathology Index have undergone the most validation.
References
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J. R. Landis,Gary G. Koch +1 more
TL;DR: A general statistical methodology for the analysis of multivariate categorical data arising from observer reliability studies is presented and tests for interobserver bias are presented in terms of first-order marginal homogeneity and measures of interob server agreement are developed as generalized kappa-type statistics.
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TL;DR: Patients with moderate-to-severe active ulcerative colitis treated with infliximab at weeks 0, 2, and 6 and every eight weeks thereafter were more likely to have a clinical response at weeks 8, 30, and 54 than were those receiving placebo.
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The risk of colorectal cancer in ulcerative colitis: a meta-analysis
TL;DR: Using new meta-analysis techniques, the risk of CRC in UC by decade of disease and defined the risk in pancolitics and children was determined and how risk varies with geography was estimated.
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Inflammation and Cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
Steven H. Itzkowitz,Xianyang Yio +1 more
TL;DR: Observations of mice genetically prone to inflammatory bowel disease also develop colorectal cancer especially in the presence of bacterial colonization offer compelling support for the role of inflammation in colon carcinogenesis.
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Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis
Matthew D. Rutter,Brian Saunders,Kay H. Wilkinson,Steve Rumbles,Gillian Schofield,Michael A. Kamm,Christopher S. Williams,Ashley B. Price,Ian C. Talbot,Alastair Forbes +9 more
TL;DR: In long-standing extensive ulcerative colitis, the severity of colonic inflammation is an important determinant of the risk of colorectal neoplasia and endoscopic and histological grading of inflammation could allow better risk stratification for surveillance programs.