Journal ArticleDOI
Influence of castration and testosterone treatment on the vasoactive intestinal peptide receptor/effector system in rat prostatic epithelial cells
TLDR
The results suggest the importance of androgens in the biosynthesis of VIP receptors and also in their coupling to adenylate cyclase by affecting the membrane fluidity.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1988-04-02. It has received 22 citations till now. The article focuses on the topics: Vasoactive intestinal peptide & Vasoactive intestinal peptide receptor.read more
Citations
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Journal ArticleDOI
Visualising androgen receptor activity in male and female mice.
TL;DR: This model demonstrates that androgens can act in these tissues directly via AR, rather than exclusively via androgen aromatisation to estrogens and activation of the estrogen receptor, and visually demonstrates the fundamental importance of AR signalling outside the normal role in the reproductive organs.
Journal ArticleDOI
Regulation of Gene Expression in Rat Prostate by Androgen and β-Adrenergic Receptor Pathways
TL;DR: Results suggest that a tight coupling between androgen receptor and beta 2-adrenergic receptor pathways may be a prerequisite for PBP expression and functional differentiation in the rat ventral prostate gland.
Journal ArticleDOI
Ontogeny of Vasoactive Intestinal Peptide Receptors in Rat Ventral Prostate
TL;DR: The values of VIP binding capacity correlate well with those observed for adenylyl cyclase between 1 and 12 months, whereas there appears to exist a great number of uncoupled VIP receptors at 0.5 and 24 months.
Journal ArticleDOI
Evidence that testosterone modulates in vivo the adenylate cyclase activity in fat cells.
TL;DR: Both the inhibitory and stimulatory responses of adenylate cyclase are promoted by testosterone through an androgen receptor-dependent mechanism, whereas promotion of the stimulatory response appears unspecific and mainly due to increased activity of the cyclase catalytic subunit.
Journal ArticleDOI
Vasoactive intestinal polypeptide receptor VPAC1 subtype is predominant in rat prostate membranes
TL;DR: This work has identified the VIP receptor subclass expressed in rat prostatic tissue through interaction with two types of high‐affinity receptors, named VPAC1 and VPAC2 receptors.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
Journal ArticleDOI
Vasoactive intestinal peptide (vip): variation of the jejuno-ileal content in the developing rat as measured by radioreceptorassay
TL;DR: The VIP content of rat jejuno-ileum (JI) with age showed a 340-fold increase and it is speculated that the rise in VIP content is related to the role of this peptide in the regulation of the gastro-intestinal function and/or the distribution of fuels in the organism.
Journal ArticleDOI
Androgen and estrogen receptors in rat ventral prostate epithelium and stroma
Ingrid Jung-Testas,Marie-Testas Groyer,Joyce Bruner-Lorand,Oscar Hechter,Etienne-Emile Baulieu,Paul Robel +5 more
TL;DR: The conclusion is led that, contrary to androgen receptor, the major part of estradiol receptor is localized in stroma, and the results of glycerol gradients are confirmed.
Journal ArticleDOI
Regulation of prostatic steroid binding protein mRNAs by testosterone
Y.-L. Zhang,Malcolm G. Parker +1 more
TL;DR: It is concluded that testosterone acts primarily within the cell nucleus to increase steady-state levels of nuclear RNA.