Journal ArticleDOI
Influence of Gestational Age, Secretor, and Lewis Blood Group Status on the Oligosaccharide Content of Human Milk.
Clemens Kunz,Christina Meyer,Maria Carmen Collado,Lena Geiger,Izaskun García-Mantrana,Bibiana Bertua-Ríos,Cecilia Martínez-Costa,Christian Borsch,Silvia Rudloff +8 more
TLDR
Investigating whether differences exist between term and preterm milk, milk from mothers with secretor or nonsecretor status, and a Lewis blood group (a+b−), (a−b+), or ( a−b−) pattern found marked differences in total and single HMOs in milk depending onLewis blood group and secretor status.Abstract:
Objectives:Human milk oligosaccharides (HMOs) are considered to play an important role for the infant. As the biotechnical production of some HMOs is feasible today and clinical studies are being designed, the individual variation of the total amount of HMOs and of single components is of paread more
Citations
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Journal ArticleDOI
Systematic review of the concentrations of oligosaccharides in human milk.
TL;DR: The data presented here contribute to the current knowledge about the composition and quantities of oligosaccharides in human milk and may foster greater understanding of the biological functions of these compounds.
Journal ArticleDOI
Human Milk Oligosaccharides Influence Neonatal Mucosal and Systemic Immunity.
TL;DR: This review will focus on the role human milk oligosaccharides (HMO) play in neonatal gastrointestinal and systemic immune development and function, and the commercial availability of large quantities of certain HMO has furthered understanding of the functions of specific HMO.
Journal ArticleDOI
Human milk: composition and health benefits.
Fabio Mosca,Maria Lorella Giannì +1 more
TL;DR: This review briefly summarizes the current knowledge on the composition of human milk and provides an overview on its functional effects on health outcomes, focusing on the latest research results.
Journal ArticleDOI
Human Milk Oligosaccharides and Immune System Development
TL;DR: HMOs seem to protect breastfed infants against microbial infections and the protective effect has been found to be exerted through cell signaling and cell-to-cell recognition events, enrichment of the protective gut microbiota, the modulation of microbial adhesion, and the invasion of the infant intestinal mucosa.
Journal ArticleDOI
Longitudinal change of selected human milk oligosaccharides and association to infants' growth, an observatory, single center, longitudinal cohort study
TL;DR: The findings on HMO concentrations over time of lactation and clusters based on 2’FL concentrations confirm previous observations and suggest that LNnT and LNT are ‘co-regulated’ with the FUT2 dependent 2‘FL concentration, with LnnT showing a positive and Lnt a negative relation.
References
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Journal ArticleDOI
Human milk oligosaccharides: Every baby needs a sugar mama
TL;DR: An accumulating body of evidence suggests that HMOs are antiadhesive antimicrobials that serve as soluble decoy receptors, prevent pathogen attachment to infant mucosal surfaces and lower the risk for viral, bacterial and protozoan parasite infections.
Journal ArticleDOI
Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides
David A. Sela,David A. Mills +1 more
TL;DR: The ability to subsist on HMO could demark infant-associated ecotypes potentially adapted to colonize the nursing infant.
Journal ArticleDOI
Variation of human milk oligosaccharides in relation to milk groups and lactational periods
Stephan Thurl,Manfred Munzert,Jobst Henker,Günther Boehm,Beate Müller-Werner,J Jelinek,Bernd Stahl +6 more
TL;DR: It can be assumed that particularly milk of non-secretor women (milk group 2) exerts a modified biological protection in the babies in comparison with milks of secretors (groups 1 and 3) during the first 3 months of lactation.
Journal ArticleDOI
Fucosylated human milk oligosaccharides vary between individuals and over the course of lactation.
Prasoon Chaturvedi,Christopher D. Warren,Mekibib Altaye,Ardythe L. Morrow,Guillermo M. Ruiz-Palacios,Larry K. Pickering,David S. Newburg +6 more
TL;DR: The patterns of milk oligosaccharides among individuals suggest the existence of many genotype subpopulations and that the protective activities of human milk could also vary among individuals and during lactation.
Journal ArticleDOI
Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants
Zachery T. Lewis,Sarah M. Totten,Jennifer T. Smilowitz,Mina Popovic,Evan A. Parker,Danielle G. Lemay,Maxwell L. Van Tassell,Michael J. Miller,Yong Su Jin,J. Bruce German,Carlito B. Lebrilla,David A. Mills +11 more
TL;DR: Mechanistic insight is provided into how milk glycans enrich specific beneficial bacterial populations in infants and clues for enhancing enrichment of bifidobacterial populations in at risk populations - such as premature infants are revealed.
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