Journal ArticleDOI
Influences of early thyroid hormone manipulations: delays in pup motor and exploratory behavior are evident in adult operant performance.
TLDR
The present results demonstrate that the pervasive and negative effects of prenatal thyroid deficiency on early behavior are also expressed during adult operant performance.About:
This article is published in Physiology & Behavior.The article was published on 2002-04-15. It has received 30 citations till now. The article focuses on the topics: Congenital hypothyroidism & Thyroid.read more
Citations
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Journal ArticleDOI
Influence of maternal thyroid hormones during gestation on fetal brain development
Nora K. Moog,Sonja Entringer,Christine Heim,Pathik D. Wadhwa,Norbert Kathmann,Claudia Buss,Claudia Buss +6 more
TL;DR: Whether and how processes related to maternal stress and stress biology may interact with and modify the effects of maternal thyroid function on offspring brain development is considered, with implications for early identification of risk, primary prevention and intervention.
Journal ArticleDOI
Developmental toxicity of polychlorinated biphenyls (PCBs): a systematic review of experimental data
Beate Ulbrich,Ralf Stahlmann +1 more
TL;DR: Interactions of PCBs with biological substrates that could mediate adverse effects observed in experimental animals and in children are focused on, and the shortcomings of many of the animal studies available are reviewed.
Journal ArticleDOI
Polychlorinated Biphenyls Disturb Differentiation of Normal Human Neural Progenitor Cells: Clue for Involvement of Thyroid Hormone Receptors
TL;DR: Results suggest that PCB-118 mimics T3 action via the TH pathway, and the PCB-mediated effect on oligodendrocyte formation was blocked by retinoic acid and the thyroid hormone receptor antagonist NH-3.
Journal ArticleDOI
Dose-dependent reductions in spatial learning and synaptic function in the dentate gyrus of adult rats following developmental thyroid hormone insufficiency.
Mary E. Gilbert,Li Sui,Li Sui +2 more
TL;DR: D dose-dependent reductions in synaptic transmission and impairments in long-term potentiation of the EPSP component of the compound field potential are revealed and extend observations associated with dentate gyrus synaptic function to a lower dose range and provide correlative evidence of behavioral disruption in a hippocampal-dependent learning task following developmental thyroid hormone insufficiency.
Journal ArticleDOI
Mode of Action: Developmental Thyroid Hormone Insufficiency—Neurological Abnormalities Resulting From Exposure to Propylthiouracil
TL;DR: While the analysis predicts that PTU doses that produce thyroid hormone insufficiency in humans would adversely affect the developing brain, careful monitoring of PTU administration in pregnant and lactating humans keeps infant serum thyroid hormone levels within the normal range.
References
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Journal ArticleDOI
Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.
James E. Haddow,Glenn E. Palomaki,Walter C. Allan,Josephine Williams,George J. Knight,June Gagnon,Cheryl E. O’heir,Marvin L. Mitchell,Rosalie J. Hermos,Susan E. Waisbren,James D. Faix,Robert Z. Klein +11 more
TL;DR: Undiagnosed hypothyroidism in pregnant women may adversely affect their fetuses; therefore, screening for thyroid deficiency during pregnancy may be warranted.
Book
Evoked Potentials in Clinical Medicine
Keith H. Chiappa,Allan H. Ropper +1 more
TL;DR: Evoked potentials in clinical medicine, Evoked Potentials in Clinical Medicine, کتابخانه مرکزی دانشگاه ایران.
Journal ArticleDOI
The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. I. Cell proliferation and differentiation.
Jean L. Nicholson,Joseph Altman +1 more
TL;DR: The role played by thyroid hormone in the initiation of cell differentiation in the central nervous system is discussed and mechanisms of differentiation of cells derived from the external granular layer are discussed.
Journal ArticleDOI
Enhanced Visual Search for a Conjunctive Target in Autism: A Research Note
TL;DR: Children with and without autism were compared on two visual search tasks in which a letter target appeared among two sets of letter distracters, and children with autism showed no significant slowing in reaction time in the conjunctive task and were faster than control children in this task.
Journal ArticleDOI
Cognitive function in non-demented older adults with hypothyroidism.
D. Osterweil,Karl Syndulko,Cohen Sn,P Pettler-Jennings,Jerome M. Hershman,Jeffrey L. Cummings,Tourtellotte Ww,David H. Solomon +7 more
TL;DR: Evaluating objectively changes in cognitive function and electrophysiologic characteristics associated with hypothyroidism of varying severity and duration in primarily older persons to determine whether these changes are reversible when a euthyroid state has been attained after treatment with thyroid hormone.
Related Papers (5)
Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings.
R. T. Zoeller,J. Rovet +1 more