Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic.
Livio Luzi,Maria Grazia Radaelli +1 more
TLDR
Due to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals, and evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response.Abstract:
Analyze the relationship between obesity and influenza. Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral strain, prolongs the virus shedding throughout the total population and eventually might increase overall mortality rate of an influenza pandemic. Waiting for the development of a vaccination against COVID-19, isolation of positive cases and social distancing are the primary interventions. Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise. Due to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.read more
Citations
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Practical recommendations for the management of diabetes in patients with COVID-19.
Stefan R. Bornstein,Francesco Rubino,Francesco Rubino,Kamlesh Khunti,Geltrude Mingrone,Geltrude Mingrone,David Hopkins,David Hopkins,Andreas L. Birkenfeld,Bernhard O. Boehm,Bernhard O. Boehm,Stephanie A. Amiel,Richard I. G. Holt,Jay S. Skyler,J. Hans DeVries,Eric Renard,Robert H. Eckel,Paul Zimmet,Kurt George Alberti,Josep Vidal,Bruno Geloneze,Juliana C.N. Chan,Linong Ji,Barbara Ludwig +23 more
TL;DR: An international panel of experts in the field of diabetes and endocrinology is formed to provide some guidance and practical recommendations for the management of diabetes during the COVID-19 pandemic.
Journal ArticleDOI
The Stanford Hall consensus statement for post-COVID-19 rehabilitation.
Robert M. Barker-Davies,Oliver O'Sullivan,Kahawalage Pumi Prathima Senaratne,Kahawalage Pumi Prathima Senaratne,Polly Baker,Polly Baker,Mark Cranley,Shreshth Dharm-Datta,Henrietta Ellis,Duncan Goodall,Michael Gough,Sarah Lewis,Jonathan Norman,Theodora Papadopoulou,David Roscoe,David Roscoe,Daniel Sherwood,Philippa Turner,Philippa Turner,Tammy Walker,Alan Mistlin,Rhodri Phillip,Alastair M. Nicol,Alastair M. Nicol,Alexander N. Bennett,Sardar Bahadur +25 more
TL;DR: This consensus statement provides an overarching framework assimilating evidence and likely requirements of multidisciplinary rehabilitation post COVID-19 illness, for a target population of active individuals, including military personnel and athletes.
Journal ArticleDOI
Predicting Mortality Due to SARS-CoV-2: A Mechanistic Score Relating Obesity and Diabetes to COVID-19 Outcomes in Mexico.
Omar Yaxmehen Bello-Chavolla,Jessica Paola Bahena-López,Neftali Eduardo Antonio-Villa,Arsenio Vargas-Vázquez,Armando González-Díaz,Alejandro Márquez-Salinas,Carlos A Fermín-Martínez,J. Jesús Naveja,Carlos A. Aguilar-Salinas +8 more
TL;DR: A mechanistic approach to evaluate risk for complications and lethality attributable to COVID-19 considering the effect of obesity and diabetes in Mexico is proposed and offers a clinical tool for quick determination of high-risk susceptibility patients in a first contact scenario.
Journal ArticleDOI
Obesity in patients with COVID-19: a systematic review and meta-analysis.
TL;DR: Obesity increases risk for hospitalization, ICU admission, IMV requirement and death among patients with CO VID-19 and excessive visceral adiposity appears to be associated with severe COVID-19 outcomes.
Journal ArticleDOI
Obesity and diabetes as high-risk factors for severe coronavirus disease 2019 (Covid-19).
TL;DR: A synthesis of the recent advances in the understanding of the relationships between obesity, diabetes and Covid‐19 along with the underlying mechanisms is presented to provide special treatment guidance for these at‐risk populations.
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