Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro and in Streptozotocin-Induced Diabetic Rats
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In this paper, the effect of methanolic extract of the leaves of Origanum majorana (OM) used as spice in many countries on AGEs formation was investigated.Abstract:
The development of AGE inhibitors is considered to have therapeutic potential in patients with diabetes diseases. The aim of the present study was investigate the effect of methanolic extract of the leaves of Origanum majorana (OM) used as spice in many countries on AGEs formation. In vitro studies indicated a significant inhibitory effects on the formation of AGEs. Their antiglycation activities were not only brought about by their antioxidant activities but also related to their trapping abilities of reactive carbonyl species such as methylglyoxal, an intermediate reactive carbonyl of AGE formation. The results demonstrate that OM have significant effects on in vitro AGE formation, and the glycation inhibitory activity was more effectively than those obtained using as standard antiglycation agent aminoguanidine. OM is a potent agent for protecting LDL against oxidation and glycation. Treatment of streptozotocin-diabetic mice with OM and glibenclamide for 28 days had beneficial effects on renal metabolic abnormalities including glucose level and AGEs formation. Diabetic mice showed increase in tail tendon collagen, glycated collagen linked fluorescence and reduction in pepsin digestion. Treatment with OM improved these parameters when compared to diabetic control and glibenclamide.read more
Citations
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The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach
TL;DR: Several new therapeutic approaches that have been applied to treat these devastating disorders, including the use of various synthetic and naturally occurring inhibitors are discussed, including modulation of the AGE-RAGE axis is considered promising in the prevention of neurodegenerative diseases.
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Management of diabetic complications: A chemical constituents based approach
TL;DR: Various medicinal plants/plant extracts containing flavonoids, alkaloids, phenolic compounds, terpenoids, saponins and phytosterol type chemical constituents were found to be effective in the management of diabetic complications.
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Inhibitory effect of phenolic compounds and plant extracts on the formation of advance glycation end products: A comprehensive review
TL;DR: The purpose of this review is to critically evaluate the existing literature on different phenolics on AGEs inhibition to find natural compounds able to prevent glycation and have the potential therapeutic ability to inhibit diabetes and age associated diseases.
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The Health Benefits of Selected Culinary Herbs and Spices Found in the Traditional Mediterranean Diet
TL;DR: The most recent research regarding the anti-diabetic, anti-inflammatory,Anti-hyperlipidemic and anti-hypertensive properties of this collection of culinary species are summarized.
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Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L.
Abdelhakim Bouyahya,Imane Chamkhi,Taoufiq Benali,Fatima-Ezzahrae Guaouguaou,Abdelaali Balahbib,Nasreddine El Omari,Douae Taha,Omar Belmehdi,Zenging Ghokhan,Naoual El Menyiy +9 more
TL;DR: The results suggest that the pharmacological properties of O. majorana confirm its traditional uses and further investigations regarding the evaluation of molecular mechanisms of identified compounds against human cancer cell lines, inflammatory process, and microbial infections are needed to validate pharmacodynamic targets.
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