Journal ArticleDOI
Inhibitory effects of S-nitrosoglutathione on cell proliferation and DNA synthesis: possible role of glyoxalase I inactivation.
TLDR
Results suggest that the inhibitory effects of GSNO on cell proliferation and DNA synthesis might be at least partly due to inactivation of Glo I, and glyoxalase I activity was consistently repressed during exposure to GSNO.About:
This article is published in Chemico-Biological Interactions.The article was published on 2001-08-31. It has received 3 citations till now. The article focuses on the topics: S-Nitrosoglutathione & Glutathione.read more
Citations
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Glutathione Homeostasis and Functions: Potential Targets forMedical Interventions
TL;DR: The principal mechanisms of the protective role of GSH against reactive species and electrophiles are characterized and a hypothesis for investigation of the physiology and biochemistry of glutathione is provided with a focus on human and animal health.
Journal ArticleDOI
Aldehyde metabolism in the cardiovascular system
Journal ArticleDOI
Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells
TL;DR: The data suggest that TRG may be a useful adjunct therapy in circumventing drug resistance in K562 leukemia cells, and suggest that the downstream effect of TRG in DOX-resistant cells may be interference with normal cell cycle events leading to genomic instability.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
Journal ArticleDOI
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
Dennis J. Stuehr,Carl Nathan +1 more
TL;DR: M phi-generated NO.
Journal ArticleDOI
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Jonathan S. Stamler,Omar Jaraki,Jihan K. Osborne,Daniel I. Simon,John F. Keaney,Joseph A. Vita,David J. Singel,C R Valeri,Joseph Loscalzo +8 more
TL;DR: It is found that naturally produced nitric oxide circulates in plasma primarily complexed in S-nitrosothiol species, principal among which is S-Nitroso-serum albumin, which likely serves as a reservoir with which plasma levels of highly reactive, short-lived free nitrics can be regulated for the maintenance of vascular tone.