Journal ArticleDOI
Injury and Repair of Ligaments and Tendons
Savio L. C. Woo,Richard E. Debski,Jennifer Zeminski,Steven D. Abramowitch,Serena S. Chan Saw,James A. Fenwick +5 more
TLDR
In this chapter, biomechanical methods used to analyze healing and repair of ligaments and tendons are initially described such that the tensile properties of these soft tissues as well as their contribution to joint motion can be determined.Abstract:
▪ Abstract In this chapter, biomechanical methods used to analyze healing and repair of ligaments and tendons are initially described such that the tensile properties of these soft tissues as well as their contribution to joint motion can be determined. The focus then turns to the important mechanical and biological factors that improve the healing process of ligaments. The biomechanics of surgical reconstruction of the anterior cruciate ligament and the key surgical parameters that affect the performance of the replacement grafts are subsequently reviewed. Finally, injury mechanisms and the biomechanical analysis of various treatment techniques for various types of tendon injuries are described.read more
Citations
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Journal ArticleDOI
The regulation of tendon stem cell differentiation by the alignment of nanofibers.
TL;DR: The aligned electrospun nanofiber structure provides an instructive microenvironment for hTSPC differentiation and may lead to the development of desirable engineered tendons.
Journal ArticleDOI
Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options.
TL;DR: Screening the genes expressed during tendon morphogenesis and determining the growth factors most crucial for tendon development will likely lead to treatment options that result in superior repair tissue and ultimately improved functional outcomes.
Journal ArticleDOI
Biomechanics of tendon injury and repair
TL;DR: The debate between intrinsic and extrinsic healing is examined, and the cellular and extracellular matrix response following a tendon injury is detailed.
Journal ArticleDOI
Stem cells in veterinary medicine--attempts at regenerating equine tendon after injury.
TL;DR: The background on why this treatment has been advocated, the data supporting its use and the current encouraging outcome from clinical use in horses treated with bone-marrow-derived cells are presented together with the future challenges of stem-cell therapy for the veterinary community.
Journal ArticleDOI
Ligament regeneration using a knitted silk scaffold combined with collagen matrix
Xiao Chen,Yi-Ying Qi,Lin-Lin Wang,Zi Yin,Guo-Li Yin,Xiaohui Zou,Hongwei Ouyang,Hongwei Ouyang +7 more
TL;DR: Results demonstrated that the knitted silk+collagen sponge scaffold improves structural and functional ligament repair by regulating ligament matrix gene expression and collagen fibril assembly.
References
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Journal ArticleDOI
A Joint Coordinate System for the Clinical Description of Three-Dimensional Motions: Application to the Knee
Edward S. Grood,W. J. Suntay +1 more
TL;DR: This paper presents a joint coordinate system that provides a simple geometric description of the three-dimensional rotational and translational motion between two rigid bodies.
Journal ArticleDOI
Tensile properties of the human femur-anterior cruciate ligament-tibia complex: The effects of specimen age and orientation
TL;DR: Values found when the femur- ACL-tibia complex was tested in the anatomical orientation were higher than those reported previously in the literature and provide new baseline data for the design and selection of grafts for ACL replacement in an attempt to reproduce normal knee kinematics.
Journal ArticleDOI
Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector.
TL;DR: These data provide the first report for establishing long-term gene transduction into mammalian muscle cells in vivo without the need for immune modulation of the organism.
Journal ArticleDOI
Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.
Thomas A. Mustoe,Glenn F. Pierce,Arlen R. Thomason,Peggy Gramates,Michael B. Sporn,Thomas F. Deuel +5 more
TL;DR: TGF-beta is a potent pharmacologic agent that can accelerate wound healing in rats and is accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF- beta.
Journal ArticleDOI
Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair.
Randell G. Young,David L. Butler,Wade Weber,Arnold I. Caplan,Stephen L. Gordon,David J. Fink +5 more
TL;DR: The results indicate that delivering mesenchymal stem cell‐contracted, organized collagen implants to large tendon defects can significantly improve the biomechanics, structure, and probably the function of the tendon after injury.