Journal ArticleDOI
Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states
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TLDR
Insulinlike growth factors, their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role.Abstract:
Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.read more
Citations
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Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors.
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Skeletal muscle dysfunction in chronic obstructive pulmonary disease.
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The IGF-I receptor in cell growth, transformation and apoptosis.
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Hormones and Growth Factors in Milk
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The growth hormone deficiency syndrome in adults
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References
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Journal ArticleDOI
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.
TL;DR: Germ-line transmission of the inactivated IGF-II gene from male chimaeras yielded heterozygous progeny that were smaller than their ES cell-derived wild-type littermates (about 60% of normal body weight) and these growth-deficient animals were otherwise apparently normal and fertile.
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Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action
TL;DR: Support is added to the concept that these peptides act through autocrine or paracrine mechanisms, being produced at multiple sites and acting at or near their sites of production.
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A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro.
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An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.
TL;DR: It is concluded that a form of IGF binding protein that is present in extracellular fluids and is secreted by many types of cells can markedly potentiate the cellular response to IGF-I.
Journal ArticleDOI
Binding proteins for the insulin-like growth factors: structure, regulation and function
Robert C. Baxter,Janet L. Martin +1 more
TL;DR: This review outlines the purification and characterization of the binding proteins that have been identified to date, and describes the regulation of their production and of their levels in the circulation.
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