Intracellular Targeting Mechanisms by Antimicrobial Peptides.
TLDR
This review focuses on the major intracellular targeting activities reported in AMPs, which include nucleic acids and protein biosynthesis and protein-folding, protease, cell division, cell wall biosynthesis, and lipopolysaccharide inhibition.Abstract:
Antimicrobial peptides (AMPs) are expressed in various living organisms as first-line host defenses against potential harmful encounters in their surroundings. AMPs are short polycationic peptides exhibiting various antimicrobial activities. The principal antibacterial activity is attributed to the membrane-lytic mechanism which directly interferes with the integrity of the bacterial cell membrane and cell wall. In addition, a number of AMPs form a transmembrane channel in the membrane by self-aggregation or polymerization, leading to cytoplasm leakage and cell death. However, an increasing body of evidence has demonstrated that AMPs are able to exert intracellular inhibitory activities as the primary or supportive mechanisms to achieve efficient killing. In this review, we focus on the major intracellular targeting activities reported in AMPs, which include nucleic acids and protein biosynthesis and protein-folding, protease, cell division, cell wall biosynthesis, and lipopolysaccharide inhibition. These multifunctional AMPs could serve as the potential lead peptides for the future development of novel antibacterial agents with improved therapeutic profiles.read more
Citations
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Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields
TL;DR: This review introduces the progress of research on AMPs comprehensively and systematically, including their classification, mechanism of action, design methods, environmental factors affecting their activity, application status, prospects in various fields and problems to be solved.
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Alternatives to Conventional Antibiotics in the Era of Antimicrobial Resistance
TL;DR: A review of the various promising approaches that have been adopted in the search for therapies that can substitute for antibiotics, including genetically modified phages, antibacterial oligonucleotides, and CRISPR-Cas9.
Dissertation
Isolation and characterization of a novel antimicrobial peptide from Bufo bufo gargarizans = 한국산 두꺼비로부터 새로운 항균 펩타이드 분리와 그 특성 연구
Chan-Bae Park,박찬배 +1 more
TL;DR: A potent and structurally novel antimicrobial peptide was isolated and characterized from the stomach tissue of Bufo bufo gargarizans, an Asian toad.
Journal ArticleDOI
Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
Réka Spohn,Lejla Daruka,Lejla Daruka,Viktória Lázár,Viktória Lázár,Ana Martins,Fanni Vidovics,Gábor Grézal,Orsolya Méhi,Bálint Kintses,Bálint Kintses,Mónika Számel,Mónika Számel,Pramod Kumar Jangir,Pramod Kumar Jangir,Bálint Csörgő,Bálint Csörgő,Ádám Györkei,Zoltán Bódi,Anikó Faragó,László Bodai,Imre Földesi,D Kata,Gergely Maróti,Bernadett Pap,Roland Wirth,Balázs Papp,Csaba Pál +27 more
TL;DR: This work indicates that evolution of resistance against certain AMPs, such as tachyplesin II and cecropin P1, is limited, and physicochemical features that make AMPs less prone to resistance and no cross- or horizontally-acquired resistance are found.
Journal ArticleDOI
Antimicrobial Polymers: The Potential Replacement of Existing Antibiotics?
Nor Fadhilah Kamaruzzaman,Li Peng Tan,Ruhil Hayati Hamdan,Siew Shean Choong,Weng Kin Wong,Amanda J. Gibson,Alexandru Chivu,Maria de Fátima Pina +7 more
TL;DR: The latest update on research related to antimicrobial polymers in the context of ESKAPE is provided, including polymer subgroups: compounds containing natural peptides, halogens, phosphor and sulfo derivatives and phenol and benzoic derivatives, organometalic polymers, metal nanoparticles incorporated into polymeric carriers, dendrimers and polymer-based guanidine.
References
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