Intracellular Transport of Viruses and Their Components: Utilizing the Cytoskeleton and Membrane Highways
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There is not sufficient information for any plant virus to create a complete model of its intracellular movement; thus, more research is needed to achieve that goal.Abstract:
Plant viruses are obligate organisms that require host components for movement within and between cells. A mechanistic understanding of virus movement will allow the identification of new methods to control virus systemic spread and serve as a model system for understanding host macromolecule intra- and intercellular transport. Recent studies have moved beyond the identification of virus proteins involved in virus movement and their effect on plasmodesmal size exclusion limits to the analysis of their interactions with host components to allow movement within and between cells. It is clear that individual virus proteins and replication complexes associate with and, in some cases, traffic along the host cytoskeleton and membranes. Here, we review these recent findings, highlighting the diverse associations observed between these components and their trafficking capacity. Plant viruses operate individually, sometimes within virus species, to utilize unique interactions between their proteins or complexes and individual host cytoskeletal or membrane elements over time or space for their movement. However, there is not sufficient information for any plant virus to create a complete model of its intracellular movement; thus, more research is needed to achieve that goal.read more
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Book ChapterDOI
Molecular biology of potyviruses.
TL;DR: An update of the knowledge on potyvirus multiplication, movement, and transmission and on potYvirus/plant compatible interactions including pathogenicity and symptom determinants is presented and information on biotechnological applications of potyviruses is provided.
Journal ArticleDOI
Intracellular Transport of Plant Viruses: Finding the Door out of the Cell
TL;DR: This review will discuss the strategies that viruses use for intracellular movement from the replication site to the PD, in particular focusing on the role of host membranes for intrACEllular transport and the coordinated interactions between virus proteins within cells that are necessary for successful virus spread.
Journal ArticleDOI
A Physical Interaction Network of Dengue Virus and Human Proteins
Sudip Khadka,Abbey D. Vangeloff,Chaoying Zhang,Prasad Siddavatam,Nicholas S. Heaton,Ling Wang,Ranjan Sengupta,Sudhir Sahasrabudhe,Glenn Randall,Michael Gribskov,Richard J. Kuhn,Rushika Perera,Douglas J. LaCount +12 more
TL;DR: Dengue virus (DENV), an emerging mosquito-transmitted pathogen capable of causing severe disease in humans, interacts with host cell factors to create a more favorable environment for replication and provides additional support for the hypothesis that viruses preferentially target cellular proteins that occupy central position in the human protein interaction network.
Journal ArticleDOI
Plasmodesmata: Gateways to Local and Systemic Virus Infection
TL;DR: As channels that provide cell-to-cell connectivity, plasmodesmata are central to the local and systemic spread of viruses in plants and the ways in which viruses bring about functional changes that allow macromolecular trafficking to occur are discussed.
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Virus factories: biogenesis and structural design
TL;DR: New inter‐organelle contacts have been visualized within virus factories, whose structure is very dynamic, as it changes over time.
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