Intrapancreatic fat deposition and visceral fat volume are associated with the presence of diabetes after acute pancreatitis
Ruma G. Singh,Aya Cervantes,Jin Uk Kim,Ngoc Nhu Nguyen,Steve V. DeSouza,Dech Dokpuang,Jun Lu,Maxim S. Petrov +7 more
TLDR
Individuals with diabetes after acute pancreatitis have significantly higher intrapancreatic fat percentage, visceral fat volume, and V/S fat volume ratio, and levels of C-reactive protein during AP are significantly associated with VFV, whereas biliary AP is significant associated with intrapANCreaticfat percentage.Abstract:
Individuals with diabetes after acute pancreatitis have significantly higher intrapancreatic fat percentage and visceral fat volume compared with individuals without diabetes after acute pancreatit...read more
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Antidiabetic Medications and Mortality Risk in Individuals With Pancreatic Cancer-Related Diabetes and Postpancreatitis Diabetes: A Nationwide Cohort Study.
TL;DR: Metformin promotes a survival benefit in individuals with PPDM but not PCRD, and reverse causality may play a role in the association between insulin use and mortality in PCRD.
Journal ArticleDOI
Trajectories of glycaemia following acute pancreatitis: a prospective longitudinal cohort study with 24 months follow-up.
Sakina H. Bharmal,Jaelim Cho,Gisselle C. Alarcon Ramos,Juyeon Ko,Charlotte E Stuart,Andre E Modesto,Ruma G. Singh,Maxim S. Petrov +7 more
TL;DR: This first prospective cohort study of changes in glycaemia showed that at least one out of five patients develops new-onset prediabetes or diabetes at 6 months of follow-up and more than four out of ten—in the first 2 years.
Journal ArticleDOI
Postpancreatitis Diabetes Confers Higher Risk for Pancreatic Cancer Than Type 2 Diabetes: Results From a Nationwide Cancer Registry
TL;DR: PPDM poses the highest risk for pancreatic cancer in individuals with diabetes, as well as their temporal relationship, according to the aim of this study.
Journal ArticleDOI
Panorama of mediators in postpancreatitis diabetes mellitus.
TL;DR: An overview of mediators involved in the pathogenesis of postacute pancreatitis diabetes mellitus is provided to provide an overview of druggable targets that offer novel opportunities to reduce the burden of pancreatitis through tertiary prevention.
Journal ArticleDOI
A Systematic Review of Intra-pancreatic Fat Deposition and Pancreatic Carcinogenesis
TL;DR: In this article, a comprehensive systematic review of clinical studies on intra-pancreatic fat deposition in individuals with pancreatic cancer or pre-malignant lesions was conducted, and the authors found that the presence of pancreatic malignancy was associated with a significantly increased risk of fat deposition (relative risk 2.78 (95% confidence interval, 1.56-4.94, p < 0.001).
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