Journal ArticleDOI
Ion Exchange Resins for Ophthalmic Delivery
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TLDR
A new novel delivery system for ophthalmic drugs was developed using an antiglaucoma agent Betaxolol Hydrochloride as a model, which optimized the bioavailability and physical stability and ease of resuspendability of the product.Abstract:
A new novel delivery system for ophthalmic drugs was developed using an antiglaucoma agent Betaxolol Hydrochloride as a model. The new delivery system involved both the binding and release of drug from ion exchange resin particles. Betaxolol was studied in-vitro via a release model analysis. The ocular comfort of Betaxolol was greatly enhanced by reducing the availability of free drug molecules in the precorneal tear film. The amount of resin concentration was selected to obtain optimum binding of the drug. The zeta potential of suspended particles was adjusted to produce flocculated suspension. Drug resin particles were then incorporated into the structured vehicle, containing Carbomer 934P as a polymer, to enhance the physical stability and ease of resuspendability of the product. This delivery system also optimized the bioavailability of Betaxolol, reducing the total drug concentration in half to 0.25% Betaxolol in 0.25% BETOPTIC S Ophthalmic Suspension as compared with 0.5% Betaxolol in BETOP...read more
Citations
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Ophthalmic drug delivery systems—Recent advances
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Recent Advances in Ocular Drug Delivery Systems
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TL;DR: There is urgent need to develop ocular drug delivery systems which provide controlled release for the treatment of chronic diseases, and increase patient's and doctor's convenience to reduce the dosing frequency and invasive treatment.
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Industrial perspective in ocular drug delivery.
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TL;DR: In the development of a commercial drug product, the formulator must consider various perspectives such as nanotechnology, microspheres and prodrugs to optimize the product and the final formulation is the ideal compromise between the three.
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Topical semi-solid drug delivery: kinetics and tolerance of ophthalmic hydrogels
TL;DR: The efficacy of ophthalmic semi-solid hydrogels is mostly based on an increase of ocular residence time, via enhanced viscosity and mucoadhesive properties, which improves bioavailability and decrease the side effects induced by the systemic absorption of topically applied Ophthalmic drugs.
References
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Journal ArticleDOI
Novel method to evaluate diffusion controlled release of drug from resinate
TL;DR: A novel method is presented to evaluate diffusion-controlled release of a drug from a resinate that is direct, simple, involves no trial and error, and is applicable to any drug-resin complex.
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Sustained‐release drug delivery system I: Coated ion‐exchange resin system for phenylpropanolamine and other drugs
TL;DR: A novel technique is reported that minimizes these variables by providing a polymeric film coating to the ion-exchange resin-drug complex particles, making drug release from these particles diffusion controlled.
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Pilocarpine Therapy with Soft Contact Lenses
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Use of hydrophilic contact lenses to increase ocular penetration of topical drugs.
TL;DR: Bionite lenses, either untreated or pretreated with fluorescein, markedly increase the concentration of this drug in the anterior segment of the eye, suggesting that these lenses may be useful adjuncts in attaining and maintaining high drug concentrations in the eye without the use of frequent topical medication.
Journal ArticleDOI
Preparation and evaluation of microencapsulated and coated ion-exchange resin beads containing theophylline.
TL;DR: It was found that the patterns of release and the rates could be controlled by the cross-linking of the resin and the coating procedures used and by using ethylcellulose microencapsulation, a coating of hard paraffin, or a combination of both.