Isolation and characterization of the mouse corticotropin‐β‐lipotropin precursor gene and a related pseudogene
Mitsue Notake,Takamasa Tobimatsu,Yumiko Watanabe,Hideo Takahashi,Masayoshi Mishina,Shosaku Numa +5 more
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TLDR
Two mouse genomic DNA sequences homologous with human corticotropin‐β‐lipotropin precursor gene sequences have been cloned and a pseudogene corresponds to the functional mouse gene sequence encoding the carboxy‐terminal 143 amino acid residues and the 3′‐untranslated region.About:
This article is published in FEBS Letters.The article was published on 1983-05-30 and is currently open access. It has received 96 citations till now. The article focuses on the topics: Lipotropin & Pseudogene.read more
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Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin.
TL;DR: It is shown that mice lacking the POMC-derived peptides have obesity, defective adrenal development and altered pigmentation, and the therapeutic use of peripheral melanocortin in the treatment of obesity is indicated.
Journal ArticleDOI
Evidence for higher rates of nucleotide substitution in rodents than in man
Chung-I Wu,Wen-Hsiung Li +1 more
TL;DR: It is found that rodents evolve significantly faster than man when the coding regions of 11 genes from rodents (mouse or rat) and man are compared with those from another mammalian species (usually bovine).
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A cyclic AMP- and phorbol ester-inducible DNA element.
TL;DR: It is reported that cAMP analogues and activators of adenylate cyclase regulate a proenkephalin-chloramphenicol acetyl trans-ferase fusion gene when transiently expressed in tissue culture cells.
Journal ArticleDOI
Isolation and structural organization of the human preproenkephalin gene
Masaharu Noda,Yutaka Teranishi,Hideo Takahashi,Mitsuyoshi Toyosato,Mitsue Notake,Shigetada Nakanishi,Shosaku Numa +6 more
TL;DR: The amino acid sequence homology observed between preproenkephalin B and preproinjector A suggests that the two genes have been generated from a common ancestor by gene duplication.
Journal ArticleDOI
Regulation of Proopiomelanocortin Gene Expression in Pituitary
TL;DR: This review will deal primarily with the regulation of POMC gene expression in rat and mouse pituitary tissues, the main site of expression is the pituitaries anterior lobe cortocotroph and intermediate lobe melanotroph.
References
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Journal ArticleDOI
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
TL;DR: In this article, the rat pancreas RNA was used as a source for the purification of alpha-amylase messenger ribonucleic acid (RBA) using 2-mercaptoethanol.
Book ChapterDOI
Sequencing end-labeled DNA with base-specific chemical cleavages.
Allan M. Maxam,Walter Gilbert +1 more
TL;DR: The chapter presents techniques for producing discrete DNA fragments, end-labeling DNA, segregating end- labeled fragments, extracting DNA from gels, and the protocols for partially cleaving it at specific bases using the chemical reactions.
Journal ArticleDOI
Screening lambdagt recombinant clones by hybridization to single plaques in situ
WD Benton,Ronald W. Davis +1 more
TL;DR: A rapid, direct method for screening single plaques of Agt recombinant phage is described, which allows at least 10(6) clones to be screened per day and simplifies physical containment of recombinants.
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Organization and Expression of Eucaryotic Split Genes Coding for Proteins
R Breathnach,P Chambon +1 more
TL;DR: This paper organizes the organization of protein codes into split genes, a small number of which are expressed in the chickenuct, and discusses generalization, generalization and Molecular Evolution.
Expression of eucaryotic split genes coding for proteins
TL;DR: In this paper, the split genes were described as follows: Globin genes expressed in the chicken o,iduct, Vitellogenin genes, Collagen genes and Actin genes.
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Most of the coding region of rat ACTH beta--LPH precursor gene lacks intervening sequences.
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