Journal ArticleDOI
Isolation and Structure of Pseurotin A, a Microbial Metabolite of Pseudeurotium ovalis STOLK with an Unusual Heterospirocyclic System
Peter Bloch,Christoph Tamm +1 more
TLDR
The structure and absolute configuration of pseurotin A, a new metabolite, isolated from culture filtrates of Pseudeurotium ovalis STOLK(Ascomycetes) has been shown to be (1, 2, 5S, 8S, 9R, 3′Z)-8-benzoyl-2 (1′, 2-dihydroxy-3′-hexenyl)-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro [4Abstract:
The structure and absolute configuration of pseurotin A, a new metabolite, isolated from culture filtrates of Pseudeurotium ovalis STOLK(Ascomycetes) has been shown to be (1′S, 2′S, 5S, 8S, 9R, 3′Z)-8-benzoyl-2 (1′,2-dihydroxy-3′-hexenyl)-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro [4,4]non-2-ene-4,6-dione (1).read more
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Mycotoxins, drugs and other extrolites produced by species in Penicillium subgenus Penicillium
TL;DR: The 58 species in Penicillium subgenus Penicillsium produce a large number of bioactive extrolites (secondary metabolites), including several mycotoxins, and several reported producers are reidentified and new producers of known extrolite families are reported for the first time.
Journal ArticleDOI
Metabolomics of Aspergillus fumigatus.
TL;DR: There is still doubt whether A. fumigatus can produce tryptoquivalins, but all isolates produce the related fumiquinazolines, and sphingofungins may have a similar role as the toxic fumonisins found in A. niger.
Journal ArticleDOI
Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS
TL;DR: This review discusses the biosynthesis of natural products generated by iterative hybrid polyketide synthases–non ribosomal peptide synthetases (PKS–NRPS) from fungi and bacteria, the programming of the enzymes and bioengineering approaches.
Journal ArticleDOI
Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp.
TL;DR: Azaspirene inhibits the endothelial migration induced by vascular endothelial growth factor in Neosartorya sp.
Journal ArticleDOI
Chemistry and biology of non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams from natural sources
TL;DR: In this article, the structural originality of these compounds, their biological properties and the synthetic efforts developed to reach them are discussed, and 157 references are cited; the review aims to emphasize the structural uniqueness and biological properties of the compounds.
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Notes - The Direct Conversion of Steroidal Δ5-3β-Alcohols to Δ5- and Δ4-3-Ketones
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Oxidation by Solids. I. Oxidation of Selected Alcohols by Manganese Dioxide
Journal ArticleDOI
Das Lösungsmittel Dimethylsulfoxid
D. Martin,A. Weise,H.-J. Niclas +2 more
TL;DR: The dipolare, aprotonische Losungsmittel Dimethylsulfoxid verfugt uber einen weiten Bereich des flussigen Aggregatzustandes, hohe Elektronendonatorfahigkeit and Polaritat.
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Isolation and structure elucidation of ovalicin
H. P. Sigg,H. P. Weber +1 more
TL;DR: The structure of ovalicin, a metabolite of the fungus Pseudeurotium ovalis with immunosuppressive activity, has been determined to be 11.5-methine-2,3,4,5-triphosphate, a major component of the polypeptide of E.coli A.
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Zur Kenntnis der Chemie einfacher Furenidone. (« β‐Hydroxyfurane»)
TL;DR: In this paper, β-hydro-xylierter Furane wird gezeigt, dass solche Stoffe im allgemeinen als α, β-ungesattigte Ketone (Δ2-Furenidone) vorliegen.