Journal ArticleDOI
Japanese encephalitis virus invasion of cell: allies and alleys
TLDR
This review gives a comprehensive update on what is known about the virus attachment and receptor system (allies) and the endocytic pathways exploited by the virus to gain entry into the cell and establish infection but also discusses crucial unresolved issues.Abstract:
The mosquito-borne flavivirus, Japanese encephalitis virus (JEV), is the leading cause of virus-induced encephalitis globally and a major public health concern of several countries in Southeast Asia, with the potential to become a global pathogen. The virus is neurotropic, and the disease ranges from mild fever to severe hemorrhagic and encephalitic manifestations and death. The early steps of the virus life cycle, binding, and entry into the cell are crucial determinants of infection and are potential targets for the development of antiviral therapies. JEV can infect multiple cell types; however, the key receptor molecule(s) still remains elusive. JEV also has the capacity to utilize multiple endocytic pathways for entry into cells of different lineages. This review not only gives a comprehensive update on what is known about the virus attachment and receptor system (allies) and the endocytic pathways (alleys) exploited by the virus to gain entry into the cell and establish infection but also discusses crucial unresolved issues. We also highlight common themes and key differences between JEV and other flaviviruses in these contexts.read more
Citations
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Journal Article
Estimated Global Incidence of Japanese Encephalitis: A Systematic review/Estimation De L'incidence Mondiale De L'encephalite Japonaise: Une Evaluation Systematique/ Incidencia Global Estimada De la Encefalitis Japonesa: Una Revision Sistematica
Grant L. Campbell,Susan L. Hills,Marc Fischer,Julie Jacobson,Charles H. Hoke,Joachim Hombach,Anthony A. Marfin,Tom Solomon,Theodore F. Tsai,Vivien Tsu,Amy Sarah Ginsburg +10 more
TL;DR: In this paper, the authors present a review of Japanese encephalitis (JE) in Asia, focusing on rural and suburban areas where rice culture and pig farming coexist.
Journal ArticleDOI
GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.
Minu Nain,Sriparna Mukherjee,Sonali Porey Karmakar,Andrienne W. Paton,James C. Paton,Malik Zainul Abdin,Anirban Basu,Manjula Kalia,Sudhanshu Vrati +8 more
TL;DR: The results indicate that GRP78, an endoplasmic reticulum chaperon of the HSP70 family, is a novel host factor involved at multiple steps of the JEV life cycle and could be a potential therapeutic target.
Journal ArticleDOI
Flavivirus Receptors: Diversity, Identity, and Cell Entry.
Mathilde Laureti,Divya Narayanan,Julio Rodriguez-Andres,John K. Fazakerley,Lukasz Kedzierski +4 more
TL;DR: Current knowledge on host-pathogen interactions, virus entry strategies and tropism is reviewed on two haemorrhagic flaviviruses, dengue virus and yellow fever virus, and two neurotropic flavivIRuses, Japanese encephalitis virus and Zika virus.
Journal ArticleDOI
Zika virus: An emergent neuropathological agent.
TL;DR: The rapid advance of the virus in the Americas and its likely association with microcephaly and Guillain–Barré syndrome make Zika an urgent public health concern.
Journal ArticleDOI
Japanese encephalitis virus activates autophagy through XBP1 and ATF6 ER stress sensors in neuronal cells.
Manish Sharma,Manish Sharma,Manish Sharma,Sankar Bhattacharyya,Kiran Bala Sharma,Shailendra Chauhan,Suramya Asthana,Suramya Asthana,Malik Zainul Abdin,Sudhanshu Vrati,Manjula Kalia +10 more
TL;DR: It is demonstrated that a crucial link exists between the ER stress pathways and autophagy in virus-infected cells, and that these processes are highly regulated during virus infection.
References
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TL;DR: The clustering of mutations that affect virulence in various flaviviruses indicates a possible receptor binding site and, together with other mutational and biochemical data, suggests a picture for the fusion-activating, conformational change triggered by low pH.
Journal ArticleDOI
Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
TL;DR: Three examples of emerging and resurging diseases of global significance are described: the resurgence of dengue in tropical and subtropical areas of the world, and the spread and establishment of Japanese encephalitis and West Nile viruses in new habitats and environments.
Journal ArticleDOI
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Mark Marsh,Ari Helenius +1 more
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