Journal ArticleDOI
Juvenile xanthogranuloma presenting as a testicular mass in infancy: a clinical and pathologic study of three cases
TLDR
Though uncommon, JXG joins several other distinctive neoplasms presenting in the infantile testis, and immunohistochemistry is an important adjunct to the histopathologic diagnosis.Abstract:
Juvenile xanthogranulomas (JXG) is a histiocytic disorder whose most common clinical presentation is a solitary cutaneous nodule in a child under 5 years of age, but it has come to be recognized that solitary extracutaneous lesions may present in a number of sites, including the soft tissues and various organs. Involvement of the genitourinary tract has been documented in children with multifocal or systemic JXG. The current report describes our experience with 3 cases of JXG presenting as a solitary mass in the testicle of infants between 2.5 and 13 months without manifestations of JXG elsewhere. The masses were intratesticular and had an infiltrative pattern of interstitial growth by mononuclear, histiocyte-like cells with replacement of seminiferous tubules and involvement of the epididymis whose pattern resembled leukemic and lymphomatous involvement of the testis. Because extracutaneous lesions of JXG may have few or no Touton giant cells, immunohistochemistry is an important adjunct to the histopathologic diagnosis. One of the previous 2 cases in the literature of JXG of the testis recurred after partial resection without an orchiectomy. Neither of the 2 youngest patients has experienced a local recurrence of JXG elsewhere in excess of 1 year since the original orchiectomy. The oldest patient, who was treated with partial orchiectomy, remains free of recurrence after 3 months of follow-up. Though uncommon, JXG joins several other distinctive neoplasms presenting in the infantile testis.read more
Citations
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Journal ArticleDOI
The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel
Sean R. Williamson,Brett Delahunt,Cristina Magi-Galluzzi,Ferran Algaba,Lars Egevad,Thomas M. Ulbright,Satish K. Tickoo,John R. Srigley,Jonathan I. Epstein,Daniel M. Berney +9 more
TL;DR: The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs utilized the framework of the 2004 classification, and incorporated the most up‐to‐date information concerning these tumours.
Journal ArticleDOI
Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades.
TL;DR: The spectrum of testicular tumors and tumor-like lesions that affect young patients (defined for purposes of this article as less than 20 years old) differs significantly from that in an older age group, and germ cell tumors remain the single largest category but are a smaller proportion than in adults.
Journal ArticleDOI
Fibrohistiocytic Tumors and Related Neoplasms in Children and Adolescents
TL;DR: The entire histogenetic concept of FHTs should be reconsidered in light of current studies, and the relationship between the fibroblast and histiocytes-dendritic cells may reflect the intrinsic capacity to transdifferentiate from one to the other morphologic and functional state.
Journal ArticleDOI
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
TL;DR: Testicular tumors in the prepubertal age are relatively rare, representing only 9.4% of the total testicular and paratesticular specimens from a 20-year review performed at a large pediatric hospital, and reports on their frequency vary because some investigators include the adolescent period, while others do not.
Journal ArticleDOI
Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification.
Malika A. Ladha,Richard M. Haber +1 more
TL;DR: A case of a congenital cutaneous giant JXG is reported and an algorithm for classifying giant JxG is proposed based on the onset of lesions (congenital and acquired), number of lesions, morphology of cutaneous/mucosal lesions, and extracutaneous manifestations.
References
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Journal ArticleDOI
Contemporary classification of histiocytic disorders
Blaise E. Favara,Alfred C. Feller,Macro Pauli,Elaine S. Jaffe,Lawrence M. Weiss,Maurizio Aricò,Peter Bucsky,R. Maarten Egeler,Göran Elinder,Helmut Gadner,Mary V. Gresik,Jan-Inge Henter,Shinsaku Imashuku,Gritta Janka-Schaub,Ron Jaffe,Stephan Ladisch,Christian Nezelof,Jon Pritchard +17 more
TL;DR: A classification of the histiocytic disorders that primarily affect children is presented in this article, where guidelines for distinguishing the exceedingly rare malignant diseases of histiocytes from large cell lymphomas through the use of a battery of special studies are provided.
Journal ArticleDOI
Dendritic cell subsets in health and disease.
Hideki Ueno,Eynav Klechevsky,Eynav Klechevsky,Rimpei Morita,Caroline Aspord,Tinghua Cao,Toshimichi Matsui,Tiziana Di Pucchio,John E. Connolly,Joseph W. Fay,Virginia Pascual,A. Karolina Palucka,Jacques Banchereau +12 more
TL;DR: It is proposed that interstitial (dermal) DCs preferentially activate humoral immunity, whereas Langerhans cells preferential induce cellular immunity.
Journal ArticleDOI
Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations.
TL;DR: A retrospective clinical and pathologic review of 174 cases documenting the cutaneous and extracutaneous manifestations in patients presenting from the neonatal period to 20 years of age finds that JXG is a proliferative disorder of dendrocytes, possibly dermal dendROcytes; thus, its clinical and Pathologic similarities to Langerhans cell histiocytosis are not entirely unexpected.
Juvenile Xanthogranulomas in the First Two Decades of Life
TL;DR: In this article, a retrospective clinical and pathologic review of 174 cases documenting the cutaneous and extracutaneous manifestations in patients presenting from the neonatal period to 20 years of age (mean 3.3 years; median 1 year).
Journal ArticleDOI
Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry.
Dirk Janssen,Dieter Harms +1 more
TL;DR: Clinical and follow-up data showed a generally favorable prognosis with a low relapse rate (7.0%) and even complete involution after incomplete resection of juvenile xanthogranuloma.
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Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry.
Dirk Janssen,Dieter Harms +1 more