Ketamine for neuropathic pain: a tiger that won't bite?
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This article is published in BJA: British Journal of Anaesthesia.The article was published on 2020-06-12 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Neuropathic pain.read more
Citations
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Journal ArticleDOI
Efficacy of ketamine in relieving neuropathic pain: a systematic review and meta-analysis of animal studies.
Monique van Velzen,Jack D.C. Dahan,Eveline L. A. van Dorp,Jeffrey S. Mogil,Carlijn R. Hooijmans,Albert Dahan +5 more
TL;DR: The authors performed a systematic review and meta-analysis of controlled studies on the efficacy of ketamine in mice and rats with a disease model of nerve injury on relief of allodynia.
Journal ArticleDOI
Narrative Review: Low-Dose Ketamine for Pain Management
Alessandro Riccardi,Mario Guarino,S Serra,Michele Spampinato,Simone Vanni,Dana Shiffer,Antonio Voza,Andrea Fabbri,F. De Iaco +8 more
TL;DR: In this article , a narrative review of the role of ketamine as an analgesic is discussed, with both known and new applications in various contexts (acute, chronic, and neuropathic pain), along with its strengths and weaknesses, especially in terms of psychomimetic, cardiovascular, and hepatic effects.
Journal ArticleDOI
Off‐label pharmacological treatment for neuropathic pain: A Delphi study by the Spanish Pain Society Neuropathic Pain Task Force
TL;DR: The use of off-label pharmacotherapies for neuropathic pain (NP) is growing relating to the many unmet needs of patients as mentioned in this paper , however, clinical guidelines fail to address it, and the available evidence is sparse and fragmented.
References
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Journal ArticleDOI
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
Nanna B. Finnerup,Nadine Attal,Simon Haroutounian,Ewan D McNicol,Ralf Baron,Robert H. Dworkin,Ian Gilron,Maija Haanpää,Per Hansson,Per Hansson,Troels S. Jensen,Troels S. Jensen,Peter R. Kamerman,Karen Lund,Andrew Moore,Srinivasa N. Raja,Andrew S.C. Rice,Andrew S.C. Rice,Michael C. Rowbotham,Emily S. Sena,Emily S. Sena,Philip J. Siddall,Philip J. Siddall,Blair H. Smith,Mark S. Wallace +24 more
TL;DR: The results support a revision of the NeuPSIG recommendations for the pharmacotherapy of neuropathic pain and allow a strong recommendation for use and proposal as first-line treatment in neuropathicPain for tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors, pregabalin, and gabapentin.
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Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
Thomas Graven-Nielsen,Sally Aspegren Kendall,Karl G. Henriksson,Mats Bengtsson,Jan Sörensen,Anders Johnson,Björn Gerdle,Lars Arendt-Nielsen +7 more
TL;DR: The present study showed that mechanisms involved in referred pain, temporal summation, muscular hyperalgesia, and muscle pain at rest were attenuated by the NMDA‐antagonist in FMS patients, and suggested a link between central hyperexcitability and the mechanisms for facilitated referred pain and temporal summary in a sub‐group of the fibromyalgia syndrome patients.
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Assessment and manifestation of central sensitisation across different chronic pain conditions.
Lars Arendt-Nielsen,Bart Morlion,Serge Perrot,Albert Dahan,Anthony H. Dickenson,Hans G. Kress,Chris Wells,Didier Bouhassira,A. Mohr Drewes +8 more
TL;DR: Some common fundamental central pain mechanisms are introduced and how they may translate into the clinical signs and symptoms across different chronic pain conditions, how to evaluate gain and loss of function using quantitative pain assessment tools, and the implications for optimising prevention and management of pain are discussed.
Journal ArticleDOI
The Effects of Ketamine on the Temporal Summation (Wind-Up) of the RIII Nociceptive Flexion Reflex and Pain in Humans
TL;DR: The wind-up phenomenon was characterized in humans by using electrophysiological recordings of the nociceptive flexion reflex and it was showed that this phenomenon, which might represent an elementary form of the central sensitization involved in various painful syndromes, depends on the activation of N-methyl-D-aspartate receptors, because it was selectively reduced after the administration of ketamine.
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Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain.
TL;DR: Ketamine (racemic) prolonged the reaction time more than ketamine (S+) and both drugs affected pain caused by repeated stimuli or stimuli of long duration equally or more than a single stimulus of short duration.