l-Arginine and COVID-19: An Update.
Ayobami Adebayo,Fahimeh Varzideh,Scott Wilson,Jessica Gambardella,Michael Eacobacci,Stanislovas S. Jankauskas,Kwame Donkor,Urna Kansakar,Valentina Trimarco,Pasquale Mone,Angela Lombardi,Gaetano Santulli +11 more
Reads0
Chats0
TLDR
In this paper, an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.Abstract:
l-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein, we present an updated systematic overview of the current evidence on the functional contribution of L-Arginine in COVID-19, describing its actions on endothelial cells and the immune system and discussing its potential as a therapeutic tool, emerged from recent clinical experimentations.read more
Citations
More filters
Journal ArticleDOI
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
Raffaele Izzo,Valentina Trimarco,Pasquale Mone,Teresita Aloe,M. Capra Marzani,A. Diana,G. De Fazio,M. Mallardo,Mauro Maniscalco,Giuseppe Marazzi,Nunzia Messina,Simone Mininni,Chiara Mussi,Girolamo Pelaia,A.E Pennisi,Pierachille Santus,Francesco Scarpelli,Francesco Tursi,Alessandro Zanforlin,Gaetano Santulli,Bruno Trimarco +20 more
TL;DR: In this article , the authors designed a survey (LINCOLN: L-Arginine and Vitamin C improves Long-COVID), assessing several symptoms that have been associated with Long-CoVID to be administered nationwide to COVID-19 survivors; the survey also included effort perception, measured using the Borg scale.
Journal ArticleDOI
Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19
Jessica Gambardella,Urna Kansakar,Celestino Sardu,Vincenzo Messina,S. S. Jankauskas,Raffaele Marfella,Paolo Maggi,Xujun Wang,Pasquale Mone,Giuseppe Paolisso,Daniela Sorriento,Gaetano Santulli +11 more
TL;DR: It is demonstrated for the first time that two specific microRNAs contained in circulating exosomes are functionally involved in thromboembolic events in COVID-19.
Journal ArticleDOI
Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial
Matteo Tosato,Riccardo Calvani,Anna Picca,Francesca Ciciarello,Vincenzo Galluzzo,Hélio José Coelho-Júnior,Angela Di Giorgio,C. Di Mario,Jacopo Gervasoni,Elisa Gremese,Paolo Maria Leone,Antonio Nesci,Annamaria Paglionico,Angelo Santoliquido,Luca Santoro,L. Santucci,Barbara Tolusso,Andrea Urbani,Federico Marini,Emanuele Marzetti,Francesco Landi +20 more
TL;DR: In this paper , a single-blind randomized, placebo-controlled trial was conducted in adults aged between 20 and 60 years with persistent fatigue attending a post-acute COVID-19 outpatient clinic, where participants were randomized 1:1 to receive twice-daily orally either a combination of 1.66 g larginine plus 500 mg liposomal vitamin C or a placebo for 28 days.
Journal ArticleDOI
What should a family physician know about nutrition and physical exercise rehabilitation’ advices to communicate to ‘long-term COVID-19’ patients?
TL;DR: The CPR ‘minimal advice’ that should be provided by FPs managing ‘long-term Covid-19’ patients with incapacity and how these guidelines can relieve the mental and physical problems, improve immunity, and accelerate the recovery process of the patients are reported.
References
More filters
Journal ArticleDOI
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
Journal ArticleDOI
Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
Journal ArticleDOI
Nitric oxide synthases: regulation and function.
TL;DR: Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS), which can be expressed in many cell types in response to lipopolysaccharide, cytokines, or other agents.
Journal ArticleDOI
Nitric oxide and the immune response
TL;DR: Its striking inter- and intracellular signaling capacity makes it extremely difficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications.
Journal ArticleDOI
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
TL;DR: The mechanism of mitochondrial RIRR highlights the central role of mitochondria-formed ROS, and all of the known ROS-producing sites and their relevance to the mitochondrial ROS production in vivo are discussed.