Journal ArticleDOI
L-theanine, a Component of Green Tea Prevents 3-Nitropropionic Acid (3-NP)-Induced Striatal Toxicity by Modulating Nitric Oxide Pathway.
Sumit Jamwal,Puneet Kumar +1 more
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TLDR
The neuroprotective potential of L-theanine involves inhibition of detrimental nitric oxide production and prevention of neurotransmitters alteration in the striatum and its possible mechanism is explored.Abstract:
L-theanine is unique amino acid which readily crosses blood brain barrier and possesses neuroprotective potential against neurodegenerative disorders including Huntington disease (HD). HD is characterized by selective loss of GABAergic medium spiny neurons. 3-nitropropionic acid (3-NP) induces a spectrum of HD-like neuropathology in rat striatum and widely used as experimental tool to study HD. Therefore, the present study was intended to investigate the effect of L-theanine against 3-NP-induced striatal toxicity and to explore its possible mechanism. Rats were administered with 3-NP for 21 days. L-theanine was given once a day, 1 h prior to 3-NP treatment for 21 days and L-NAME (10 mg/kg, i.p.), NO inhibitor and L-arginine (50 mg/kg; i.p.), NO precursor were administered 1 h prior to L-theanine treatment. Body weight and behavioral observation were made on weekly basis. On the 22nd day, animals were sacrificed, and the striatum was isolated for biochemical (LPO, GSH, and nitrite), pro-inflammatory cytokines and neurochemical analysis. 3-NP treatment significantly altered body weight, locomotor activity, motor coordination, mitochondrial complex-II activity, oxidative defense, pro-inflammatory mediators, and striatal neurotransmitters level. L-theanine pre-treatment (25 and 50 mg/kg/day, p.o.) significantly prevented these alterations. In addition, concurrent treatment of L-NAME with L-theanine (25 mg/kg/day, p.o.) significantly enhanced protective effect of L-theanine (25 mg/kg/day, p.o.) whereas concurrent treatment of L-arginine with L-theanine (50 mg/kg/day, p.o.) significantly ameliorated the protective effect of L-theanine (50 mg/kg/day, p.o.). The neuroprotective potential of L-theanine involves inhibition of detrimental nitric oxide production and prevention of neurotransmitters alteration in the striatum.read more
Citations
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Journal ArticleDOI
Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases.
TL;DR: The neuro protection and the mechanisms of tea and its bioactive components are reviewed and the potential challenges and future work are discussed.
Journal ArticleDOI
Insight Into the Emerging Role of Striatal Neurotransmitters in the Pathophysiology of Parkinson's Disease and Huntington's Disease: A Review
Sumit Jamwal,Puneet Kumar +1 more
TL;DR: There is an urgent need to identify more specific drugs and drug targets that can restore the al-tered neurotransmitters level in brain and prevent/delay neurodegeneration.
Journal ArticleDOI
Rutin and Selenium Co-administration Reverse 3-Nitropropionic Acid-Induced Neurochemical and Molecular Impairments in a Mouse Model of Huntington’s Disease
Mohamed S. Abdelfattah,Sherif E. A. Badr,Sally A Lotfy,Gouda H. Attia,Ahmed M. Aref,Ahmed E. Abdel Moneim,Rami B. Kassab +6 more
TL;DR: RSe co-administration may prevent or delay the progression of Huntington’s disease and its associated impairments through its antioxidant, anti-inflammatory,Anti-apoptotic, and neuromodulatory effects.
Journal ArticleDOI
Nutritional applications and beneficial health applications of green tea and l-theanine in some animal species: A review
Mahmoud Alagawany,Mohamed E. Abd El-Hack,Muhammad Saeed,Muhammad Naveed,Muhammad Naveed,Muhammad Asif Arain,Muhammad Arif,Ruchi Tiwari,Rekha Khandia,Sandip Kumar Khurana,Kumaragurubaran Karthik,Mohd Iqbal Yatoo,Ashok Munjal,Prakash Chandra Bhatt,Khan Sharun,Hafiz M.N. Iqbal,Chao Sun,Kuldeep Dhama +17 more
TL;DR: This review will be a guideline for researchers and entrepreneurs who want to explore the utilization of feeds supplemented with green tea and green tea by-products for the enhancement of livestock production.
Journal ArticleDOI
L-theanine: an astounding sui generis amino acid in poultry nutrition.
Muhammad Saeed,Muhammad Sajjad Khan,Asghar Ali Kamboh,Mahmoud Alagawany,Asmaa F. Khafaga,Ahmed E. Noreldin,Muhammad Qumar,Muhammad Safdar,Mubashar Hussain,Mohamed E. Abd El-Hack,Sun Chao +10 more
TL;DR: The aim of this review is to encourage the veterinarian and poultry researchers to conduct more research at the molecular level about this L-theanine to expose its more beneficial effects and its mechanism of absorption for potential use of this unique green tea AA in poultry nutrition.
References
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