Journal ArticleDOI
Lack of benefit from semi-annual screening for cancer of the lung : follow-up report of a randomized controlled trial on a population of high-risk males in Czechoslovakia
TLDR
Comparison of the two groups showed a higher incidence of lung cancer in the intervention group, despite the follow‐up period when both groups received annual examinations, and there was no significant difference in mortality between the 2 groups.Abstract:
Cigarette-smoking males (6,364), aged 40-64, were randomized into an intervention group which received 6-monthly screening by chest X-ray and sputum cytology, and a control group which received no asymptomatic investigation. After 3 years, both groups entered a follow-up period during which they received annual chest X-rays. Lung cancer cases detected by screening were identified at an earlier stage, more often resectable, and had a significantly better survival than "interval" cases diagnosed mainly because of symptoms. Comparison of the 2 groups showed a higher incidence of lung cancer in the intervention group, despite the follow-up period when both groups received annual examinations. There was no significant difference in mortality between the 2 groups.read more
Citations
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Journal ArticleDOI
Design of the prostate, lung, colorectal and ovarian (PLCO) cancer screening trial
Philip C. Prorok,Gerald L. Andriole,Robert S. Bresalier,Saundra S. Buys,David Chia,E. David Crawford,Ronald Fogel,Edward P. Gelmann,Fred Gilbert,Marsha A. Hasson,Richard B. Hayes,Christine Cole Johnson,Jack S. Mandel,Albert Oberman,Barbara O'Brien,Martin M. Oken,Sameer Rafla,Douglas T. Reding,Wilmer M. Rutt,Joel L. Weissfeld,Lance A. Yokochi,John K. Gohagan +21 more
TL;DR: Eligibility, consent, and other design features of the trial, randomization and screening procedures, and an outline of the follow-up procedures are described and a data analysis plan is presented.
Journal ArticleDOI
Mass screening for lung cancer with mobile spiral computed tomography scanner
Shusuke Sone,Shodayu Takashima,Feng Li,Z.-G. Yang,Takayuki Honda,Yuichiro Maruyama,M. Hasegawa,Takeshi Yamanda,Keishi Kubo,Kazuhisa Hanamura,Kazuhiro Asakura +10 more
TL;DR: In this paper, a mass screening with a spiral computed tomography scanner could contribute substantially to detection of smaller cancers, and decrease mortality, and the lung cancer detection rate with CT was significantly higher than the 0·03-0·05% for standard mass assessments done previously in the same area.
Journal ArticleDOI
Screening by Chest Radiograph and Lung Cancer Mortality: The Prostate, Lung, Colorectal, and Ovarian (PLCO) Randomized Trial
Martin M. Oken,Willam G. Hocking,Paul A. Kvale,Gerald L. Andriole,Saundra S. Buys,Timothy R. Church,E. David Crawford,Mona N. Fouad,Claudine Isaacs,Douglas J. Reding,Joel L. Weissfeld,Lance A. Yokochi,Barbara O'Brien,Lawrence R. Ragard,Joshua M. Rathmell,Thomas L. Riley,Patrick Wright,Neil Caparaso,Ping Hu,Grant Izmirlian,Paul F. Pinsky,Philip C. Prorok,Barnett S. Kramer,Anthony B. Miller,John K. Gohagan,Christine D. Berg +25 more
TL;DR: Annual screening with chest radiograph did not reduce lung cancer mortality compared with usual care in the PLCO Cancer Screening Trial.
Journal ArticleDOI
Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy
William C. Black,H G Welch +1 more
TL;DR: Over the past two decades a vast new armamentarium of diagnostic techniques has revolutionized the practice of medicine and enhanced the physician's potential for understanding disease and treating patients but also create confusion that may ultimately be harmful to patients.
Journal ArticleDOI
Early stage and locally advanced (non-metastatic) non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
TL;DR: Diagnosis and treatment of early stages theoretically represent the most consistent possibility of modifying the outcome of NSCLC in terms of disease-free and overall survival.
References
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Journal ArticleDOI
On distribution-free tests for equality of survival distributions
Robert E. Tarone,James S. Ware +1 more
Journal ArticleDOI
Screening for early lung cancer. Results of the Memorial Sloan-Kettering study in New York.
Myron R. Melamed,Myron R. Melamed,Betty J. Flehinger,Betty J. Flehinger,Muhammad B. Zaman,Muhammad B. Zaman,Robert T. Heelan,Robert T. Heelan,Wendy A. Perchick,Wendy A. Perchick,Nael Martini,Nael Martini +11 more
TL;DR: The Memorial Sloan-Kettering lung cancer screening program was begun in 1974 to evaluate sputum cytology as a supplement to the annual chest x-ray examination for early detection and diagnosis, and it is suggested that the squamous carcinomas detected by cytologic examination alone are very slow growing and tend to remain localized until detectable by x-rays.
Book
Screening in Chronic Disease
TL;DR: The natural history of disease in relation to measures of disease frequency Early detection: Sensitivity and lead time Assessing the value of early treatment: Experimental studies and nonexperimental studies The clinical course of screen-detected disease The feasibility of screening nrograms Formulation of screening policy: Response curves and determinants of outcome Cancer of the breast Arteriosclerotic vascular disease Cancer of cancer of the cervix References Index
Journal ArticleDOI
Screening in Chronic Disease
TL;DR: This chapter discusses the natural history of disease in relation to measures of disease frequency and the clinical course of screen-detected disease, and the feasibility of screening nrograms and response curves and determinants of outcome.
Journal ArticleDOI
Lung cancer detection. Results of a randomized prospective study in Czechoslovakia.
TL;DR: The study confirmed the ability of radiologic screening to detect lung cancer at an earlier stage when treatment by resection can be accomplished and the absolute numbers of 5‐year survivors detected by screening were practically the same for either compared screening frequency.