Journal ArticleDOI
Lack of Hemodynamic Forces Triggers Apoptosis in Vascular Endothelial Cells
TLDR
It is shown that the lack of hemodynamic forces triggers apoptosis in endothelial cells, hinting at mechanical forces as essential stimuli for the maintenance of blood vessels.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1997-02-24. It has received 172 citations till now. The article focuses on the topics: Vascular endothelial growth factor B & Vasculogenesis.read more
Citations
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Journal ArticleDOI
Hemodynamic shear stress and its role in atherosclerosis.
TL;DR: The functional regulation of the endothelium by local hemodynamic shear stress provides a model for understanding the focal propensity of atherosclerosis in the setting of systemic factors and may help guide future therapeutic strategies.
Journal ArticleDOI
Laminar Shear Stress Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force
Oren Traub,Bradford C. Berk +1 more
TL;DR: The ability of shear stress to modulate atherogenesis via its effects on endothelial-mediated alterations in coagulation, leukocyte and monocyte migration, smooth muscle growth, lipoprotein uptake and metabolism, and endothelial cell survival is explored.
Journal ArticleDOI
Fluid shear stress and the vascular endothelium: for better and for worse.
Nitzan Resnick,Hava Yahav,Ayelet Shay-Salit,Moran Shushy,Shay Schubert,Limor Chen Michal Zilberman,Efrat Wofovitz +6 more
TL;DR: The current review attempts to bring together recent findings on the in vivo and in vitro responses of the vascular endothelium to shear stress to address some of the questions raised above.
Journal ArticleDOI
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Andreas Schober,Maliheh Nazari-Jahantigh,Yuanyuan Wei,Kiril Bidzhekov,Felix Gremse,Jochen Grommes,Remco T. A. Megens,Kathrin Heyll,Heidi Noels,Michael Hristov,Shusheng Wang,Fabian Kiessling,Eric N. Olson,Christian Weber +13 more
TL;DR: It is shown that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and thereby prevents atherosclerotic lesion formation and introduces a potential therapeutic approach.
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Aneurysm Growth Occurs at Region of Low Wall Shear Stress. Patient-Specific Correlation of Hemodynamics and Growth in a Longitudinal Study
Loic Boussel,Vitaliy L. Rayz,Charles E. McCulloch,Alastair J. Martin,Gabriel Acevedo-Bolton,Michael T. Lawton,Randall T. Higashida,Wade S. Smith,William L. Young,David Saloner +9 more
TL;DR: The results indicate that aneurysm growth is likely to occur in regions where the endothelial layer lining the vessel wall is exposed to abnormally low wall shear stress.
References
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Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
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Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
TL;DR: It is shown here that this morphological change is closely associated with excision of nucleosome chains from nuclear chromatin, apparently through activation of an intracellular, but non-lysosomal, endonuclease.
Journal ArticleDOI
Mechanotransduction across the cell surface and through the cytoskeleton
TL;DR: The results suggest that integrins act as mechanoreceptors and transmit mechanical signals to the cytoskeleton, which may be mediated simultaneously at multiple locations inside the cell through force-induced rearrangements within a tensionally integrated cytos skeleton.
Journal ArticleDOI
Features of apoptotic cells measured by flow cytometry
Zbigniew Darzynkiewicz,S. Bruno,G. Del Bino,Wojciech Gorczyca,Michel A. Hotz,P. Lassota,Frank Traganos +6 more
TL;DR: The present review describes several methods to characterize and differentiate between two different mechanisms of cell death, apoptosis and necrosis, applied to studies of apoptosis triggered in the human leukemic HL-60 cell line by DNA topoisomerase I or II inhibitors, and in rat thymocytes by either topoisomersase inhibitors or prednisolone.
Journal ArticleDOI
Flow effects on prostacyclin production by cultured human endothelial cells.
TL;DR: The steady-state production rate of cells subjected to pulsatile shear stress was more than twice that of cells exposed to steadyShear stress and 16 times greater than that of Cells in stationary culture.
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Hemodynamic shear stress and its role in atherosclerosis.
Laminar Shear Stress Mechanisms by Which Endothelial Cells Transduce an Atheroprotective Force
Oren Traub,Bradford C. Berk +1 more