Journal ArticleDOI
Large offspring syndrome in cattle and sheep.
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TLDR
Four different situations have been identified that result in the large offspring syndrome: in vitro embryo culture, asynchronous embryo transfer into an advanced uterine environment, nuclear transfer and maternal exposure to excessively high urea diets.Abstract:
Bovine and ovine embryos exposed to a variety of unusual environments prior to the blastocyst stage have resulted in the development of unusually large offspring which can also exhibit a number of organ defects. In these animals, the increased incidence of difficult parturition and of fetal and neonatal losses has limited the large-scale use of in vitro embryo production technologies commonly used in humans and other species. Four different situations have been identified that result in the syndrome: in vitro embryo culture, asynchronous embryo transfer into an advanced uterine environment, nuclear transfer and maternal exposure to excessively high urea diets. However, programming of the syndrome by all of these situations is unpredictable and not all of the symptoms described have been observed universally. Neither the environmental factors inducing the large offspring syndrome nor the mechanisms of perturbation occurring in the early embryo and manifesting themselves in the fetus have been identified.read more
Citations
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Postnatal phenotype of dairy cows is altered by in vitro embryo production using reverse X-sorted semen
Luiz Gustavo Bruno Siqueira,Luiz Gustavo Bruno Siqueira,Serdal Dikmen,M. Sofia Ortega,Peter J. Hansen +4 more
TL;DR: Procedures associated with in vitro production of embryos involving use of reverse-sorted spermatozoa for fertilization result in an alteration of embryonic programming that persists postnatally and causes an effect on milk production in adulthood.
Journal ArticleDOI
A background to nuclear transfer and its applications in agriculture and human therapeutic medicine.
TL;DR: Some of the factors associated with the success of embryo development following nuclear transfer are reviewed and the potential uses of the technology are outlined.
Journal ArticleDOI
The monitoring of bovine pregnancies derived from transfer of in vitro produced embryos.
M. A. M. Taverne,S. P. Breukelman,Z. Perenyi,Steph J. Dieleman,Peter L.A.M. Vos,Herman Jonker,Lisette de Ruigh,Jannecke M. Van Wagtendonk-de Leeuw,Jean-François Beckers +8 more
TL;DR: This paper reviews some recent data on return rates, late embryonic and foetal losses in recipients after the transfer of either MOET, IVF or nuclear transfer embryos, and discusses possibilities to measurefoetal body sizes, size of placentomes and Foetal heart rate by means of transrectal or transabdominal ultrasonography.
Journal ArticleDOI
Restricted feed intake in lactating primiparous sows. I. Effects on sow metabolic state and subsequent reproductive performance
TL;DR: Overall, catabolism negatively affected litter weaning weight and embryonic development of the next litter, but the extent to which individual sows used tissue mobilisation to support these litter outcomes was highly variable.
Journal ArticleDOI
DNA methylomes of bovine gametes and in vivo produced preimplantation embryos.
Zongliang Jiang,Jianan Lin,Jianan Lin,Dong Hong,Zheng Xinbao,Sadie L. Marjani,Jingyue Duan,Zhengqing Ouyang,Zhengqing Ouyang,Jingbo Chen,Xiuchun Cindy Tian +10 more
TL;DR: Genome-wide gene-specific DNA methylation in bovine sperm, oocytes and preimplantation embryos is determined using reduced representation bisulfite sequencing to provide insights into the complex epigenetic reprogramming of bovines early embryos.
References
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Journal ArticleDOI
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Peng Liang,Arthur B. Pardee +1 more
TL;DR: A method to separate and clone individual messenger RNAs (mRNAs) by means of the polymerase chain reaction using a set of oligonucleotide primers, one being anchored to the polyadenylate tail of a subset of mRNAs, the other being short and arbitrary in sequence so that it anneals at different positions relative to the first primer.
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Enhanced rates of cleavage and development for sheep zygotes cultured to the blastocyst stage in vitro in the absence of serum and somatic cells: amino acids, vitamins, and culturing embryos in groups stimulate development.
TL;DR: Investigation of sheep zygote development of amino acids, ammonium, vitamins, and culture of embryos in groups in Synthetic Oviduct Fluid medium supplemented with BSA found indirect evidence that ruminant embryos utilize amino acids to a greater extent than do rodent embryos.
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Lamb birth weight is affected by culture system utilized during in vitro pre-elongation development of ovine embryos.
TL;DR: The data suggest that different culture conditions can produce embryos with differing morphology, apparent chemical composition, and rate of development, resulting in lambs with differing gestation length and birth weight.
Journal ArticleDOI
DNA methylation and imprinting: why bother?
TL;DR: It is proposed that DNA methylation is only important for the somatic lineages, but has no role in embryonic lineages including the germ line, suggesting imprinting having no intrinsic role in mammalian development.
Journal ArticleDOI
The production of unusually large offspring following embryo manipulation: Concepts and challenges
TL;DR: The production of large offspring after embryo manipulation casts new perspectives on the roles of reproductive technology in both livestock and human reproduction and an understanding of the underlying cellular mechanisms should lead to improved procedures for the handling and manipulation of embryos.