Left ventricular global function index assessed by cardiovascular magnetic resonance for the prediction of cardiovascular events in ST-elevation myocardial infarction
Ingo Eitel,Janine Pöss,Alexander Jobs,Charlotte Eitel,S. de Waha,Joerg Barkhausen,Steffen Desch,Holger Thiele +7 more
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TLDR
The LVGFI strongly correlates with markers of severe myocardial and microvascular damage in patients with STEMI, offering prognostic information beyond traditional cardiac risk factors including the LVEF.Abstract:
The left ventricular performance index (LVGFI) as a comprehensive marker of cardiac performance integrates LV structure with global function within one index. In a prospective cohort study of healthy individuals the LVGFI demonstrated a superior prognostic value as compared to LV ejection fraction (LVEF). In patients after ST-segment elevation myocardial infarction (STEMI), however, the role of the LVGFI is unknown. Aim of this study was to investigate the relationship between the LVGFI and infarct characteristics as well as prognosis in a large multicenter STEMI population. In total 795 STEMI patients reperfused by primary angioplasty (<12 h after symptom onset) underwent cardiovascular magnetic resonance (CMR) at 8 centers. CMR was completed within one week after infarction using a standardized protocol including LV dimensions, mass and function for calculation of the LVGFI. The primary clinical endpoint of the study was the occurrence of major adverse cardiac events (MACE). The median LVGFI was 31.2 % (interquartile range 25.7 to 36.6). Patients with LVGFI < median had significantly larger infarcts, less myocardial salvage, a larger extent of microvascular obstruction, higher incidence of intramyocardial hemorrhage and more pronounced LV dysfunction (p < 0.001 for all). MACE and mortality rates were significantly higher in the LVGFI < median group (p < 0.001 and p = 0.003, respectively). The LVGFI had an incremental prognostic value in addition to LVEF for prediction of all-cause mortality. The LVGFI strongly correlates with markers of severe myocardial and microvascular damage in patients with STEMI, offering prognostic information beyond traditional cardiac risk factors including the LVEF. ClinicalTrials.gov: NCT00712101read more
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Cardiac Magnetic Resonance Myocardial Feature Tracking for Optimized Prediction of Cardiovascular Events Following Myocardial Infarction
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TL;DR: CMR-FT is a superior measure of LV function and performance early after reperfused MI with incremental prognostic value for mortality over and above LV ejection fraction and infarct size and emerged as an independent predictor of poor prognosis following MI even after adjustment for established prognostic markers.
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Left ventricular global function index predicts incident heart failure and cardiovascular disease in young adults: the coronary artery risk development in young adults (CARDIA) study.
Chike C. Nwabuo,Chike C. Nwabuo,Henrique T. Moreira,Henrique T. Moreira,Henrique Doria de Vasconcellos,Nathan Mewton,Anders Opdahl,Kofo O. Ogunyankin,Bharath Ambale-Venkatesh,Pamela J. Schreiner,Anderson C. Armstrong,Cora E. Lewis,David R. Jacobs,Donald M. Lloyd-Jones,Samuel S. Gidding,Joao A.C. Lima +15 more
TL;DR: LVGFI is a strong, independent predictor of incident HF and CVD that provides incremental prognostic value compared with LVEF and male sex, black race, obesity, hypertension, and smoking are associated with worse LVGFI in the early adult lifespan.
Journal ArticleDOI
Role of Cardiac Magnetic Resonance to Improve Risk Prediction Following Acute ST-Elevation Myocardial Infarction.
TL;DR: An overview of the current impact of CMR imaging on optimized risk assessment soon after acute ST-elevation myocardial infarction is provided.
Journal ArticleDOI
Major Adverse Cardiovascular Events: An Inevitable Outcome of ST-elevation myocardial infarction? A Literature Review.
TL;DR: The current literature review found out the incidence of MACE was 4.2 % to 51% irrespective of the mode of treatment, and follow-ups lasting up to 10 years from the time of STEMI diagnosis.
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