Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis.
TLDR
Patients suffering from American cutaneous leishmaniasis showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ Blast T cells in cultures and the levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured.Abstract:
Fourteen patients suffering from American cutaneous leishmaniasis were studied. Assays of the lymphocyte proliferative response induced in vitro by Leishmania braziliensis antigens were performed. After 5 days in culture, L. braziliensis-stimulated blast T cells were harvested for CD4+ and CD8+ phenotype analysis. When results before and at the end of therapy were compared, leishmaniasis patients showed an increase in the percentage of CD8+ blast T cells and a decline in the proportion of CD4+ blast T cells in cultures. The levels of gamma interferon in T-cell culture supernatants showed a tendency to increase when the patients were cured. These results show a pattern of higher proportions of Leishmania-reactive CD8+ T cells and lower proportions of Leishmania-reactive CD4+ T cells after cure.read more
Citations
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Journal ArticleDOI
Possible interrelationship of inflammatory cells in dry type cutaneous leishmaniasis
TL;DR: Characterizing the number, distribution, co-localization, and interrelation of 4 types of inflammatory cells in different clinical forms of dry-type cutaneous leishmaniasis could be used as a baseline to design and study the new targeted therapy of synergistic effects of macrophages and DCs to phagocytizing leishmania bodies.
Dissertation
Diagnóstico de la leishmaniosis críptica en el perro. Expresión isotípica e idiotípica de los anticuerpos producidos en distintas fases de la infección
TL;DR: In this article, a large number of perros seropositivos asintomaticos are reported to have been infected by leishmaniosis canina, and the perfil clinico de this infeccion is variable, and desde a evolucion con cura espontanea a una resolocion fatal, in funcion de la respuesta inmune que desarrolle el animal a lo largo de la infección.
Journal ArticleDOI
Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis.
Rym Chamakh-Ayari,Rym Chamakh-Ayari,Mehdi Chenik,Ahmed Sahbi Chakroun,Narges Bahi-Jaber,Karim Aoun,Amel Meddeb-Garnaoui +6 more
TL;DR: RLmlRAB protein and its divergent carboxy-terminal part induced a predominant Th1 response in individuals immune to L. major or L. infantum and the results suggest that rLlamRAB and rLMLRABC proteins are potential cross-species vaccine candidates against cutaneous and visceral leishmaniasis.
Book
Studies on Immunology of Leishmania Mexicana
TL;DR: It was shown that DNA immunisation using L. mexicana gp63 generated the highest immunity to the parasite among the four tested vaccines where the killed leishmania vaccine and L.mexicANA gp63 transfected CT26 tumour cells did not generate significant immunity.
Journal ArticleDOI
Activated cytotoxic T cells within zoonotic cutaneous leishmaniasis lesions.
Thouraya Boussoffara,Thouraya Boussoffara,Mohamed Samir Boubaker,Melika Ben Ahmed,Melika Ben Ahmed,Mourad Mokni,Salma Feriani,Afif Ben Salah,Afif Ben Salah,Afif Ben Salah,Hechmi Louzir,Hechmi Louzir +11 more
TL;DR: This study investigated the involvement of cytotoxic cells on the outcome of the disease and found polymorphic clinical manifestations which could be attributed to the host's immune response.
References
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Journal ArticleDOI
Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.
TL;DR: Data establish CD4+ cells as the primary source of IFN-gamma in healing mice and of IL-4 and IL-10 during progressive infection and confirm that the spectral extremes of this disease are characterized by the presence of CD4- cells expressing Th1 or Th2 phenotypes in vivo.
Journal Article
IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.
TL;DR: Levels of IFN-gamma at the time of infection or immunization dramatically alters the type of response elicited: high levels ofIFN-Gamma favor Th1 type responses, whereas low levels promote a Th2 response.
Journal ArticleDOI
Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major.
TL;DR: In the present study, "susceptible" mice injected with a small number of parasites mounted a cell-mediated response and acquired resistance to a larger, normally pathogenic, challenge and may be applicable in diseases in which protection is dependent on cell- mediated immunity.
Journal Article
Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.
TL;DR: The production of IFN-gamma during the initial interaction of the parasite and host cells appears to be a major component of genetic control of natural resistance to infection with L. major in C3H/HeN mice.
Journal ArticleDOI
Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets.
TL;DR: The data are consistent with the expansion of type 1 helper cells during healing and type 2 helper cells (Th2) during progressive leishmania infection.