Journal ArticleDOI
Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus
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TLDR
Behavioural results showed a single injection of LPS impaired escape latency in both the acquisition and retention phases of the study, whereas a daily injection ofLPS did not significantly impair acquisition or retention.About:
This article is published in Behavioural Brain Research.The article was published on 2001-09-28. It has received 236 citations till now. The article focuses on the topics: Water maze & Dentate gyrus.read more
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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
TL;DR: It is shown that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neuroGenesis after endotoxin-induced inflammation and augments neurogenescence after cranial irradiation.
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Long-Term Potentiation and Memory
TL;DR: Lynch et al. as mentioned in this paper identified the cellular and molecu... cellular and memory cells in neuroscience is one of the most significant challenges in neuroscience and identified the most important genes for long-term potentiation and memory.
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Immune modulation of learning, memory, neural plasticity and neurogenesis
Raz Yirmiya,Inbal Goshen +1 more
TL;DR: These effects are mediated by inflammation-induced neuronal hyper-excitability and adrenocortical stimulation, followed by reduced production of neurotrophins and other plasticity-related molecules, facilitating many forms of neuropathology associated with normal aging as well as neurodegenerative and neuropsychiatric diseases.
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Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation
Jae Woong Lee,Yong Kyung Lee,Dong Yeon Yuk,Dong Young Choi,Sang Bae Ban,Ki Wan Oh,Jin Tae Hong +6 more
TL;DR: This study suggests that neuro-inflammatory reaction could contribute to AD pathology, and anti-inflammatory agent could be useful for the prevention of AD.
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Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice
Jiayi Zhao,Wei Bi,Shu Xiao,Xin Lan,Xiaofeng Cheng,Jiawei Zhang,Daxiang Lu,Wei Wei,Yanping Wang,Hongmei Li,Yong-Mei Fu,Lihong Zhu +11 more
TL;DR: The data suggest that LPS induced cognitive impairment and neuroinflammation via microglia activation by activating the NF-kB signaling pathway; furthermore, the time points, doses, methods and outcomes of LPS administration between intraperitoneal and intracerebroventricular injections are compared.
References
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A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.
Timothy V. P. Bliss,T. Lømo +1 more
TL;DR: The after‐effects of repetitive stimulation of the perforant path fibres to the dentate area of the hippocampal formation have been examined with extracellular micro‐electrodes in rabbits anaesthetized with urethane.
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Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
TL;DR: The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.
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Selective impairment of learning and blockade of long-term potentiation by an N -methyl-D-aspartate receptor antagonist, AP5
TL;DR: This article showed that chronic intraventricular infusion of D,L-AP5 causes a selective impairment of place learning, which is highly sensitive to hippocampal damage, without affecting visual discrimination learning.
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Synaptic plasticity and memory: an evaluation of the hypothesis
TL;DR: It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.