Journal ArticleDOI
Liposomes containing paramagnetic macromolecules as MRI contrast agents
TLDR
The use of paramagnetic ions, bound to macromolecules and trapped in liposomes, as MRI contrast agents is suggested and the system of Mn2+ bound to serum proteins was tested, finding that the binding of the metal ions to the macromolescules enhances their relaxation and at the same time decreases their rate of diffusion out of the liposome.Abstract:
The use of paramagnetic ions, bound to macromolecules and trapped in liposomes, as MRI contrast agents is suggested. As an example, the system of Mn2+ bound to serum proteins was tested. The binding of the metal ions to the macromolecules enhances their relaxation and at the same time decreases their rate of diffusion out of the liposomes. The use of liposomes is expected to reduce the potential toxicity of the paramagnetic ions and allows their targeting toward specific tissues. © 1986 Academic Press, Inc.read more
Citations
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Journal ArticleDOI
Macromolecules, Dendrimers, and Nanomaterials in Magnetic Resonance Imaging: The Interplay between Size, Function, and Pharmacokinetics
TL;DR: In this review, small molecule agents are introduced, but focus primarily on macromolecular MR contrast agents, particularly those containing gadolinium (Gd 3+ ) that are assembled or based in part on these same small molecules.
Journal ArticleDOI
Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging.
Willem J. M. Mulder,Gustav J. Strijkers,Geralda A. F. van Tilborg,Arjan W. Griffioen,Klaas Nicolay +4 more
TL;DR: An overview of different lipidic nanoparticles for use in MRI is given, with the main emphasis on Gd–based contrast agents.
Journal ArticleDOI
Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement.
TL;DR: Liposomes, an early version of LNPs, are a versatile nanomedicine delivery platform for treatment of a variety of diseases, such as antitumor and nucleic acid therapeutics and vaccine delivery systems as mentioned in this paper.
Journal ArticleDOI
Transverse relaxation of solvent protons induced by magnetized spheres: application to ferritin, erythrocytes, and magnetite
Pierre Gillis,Seymour H. Koenig +1 more
TL;DR: On the basis of the agreement of theory with data for solutions of small paramagnetic complexes, large magnetite particles, and liver containing low‐density polymer‐coated magnetite agglomerates, it is argued that the theory is sufficiently reliable so that, e.g., for ferritin, it appears that diffusion through intracellular gradients determines 1/T2.
Journal ArticleDOI
Liposomes: Clinical Applications and Potential for Image-Guided Drug Delivery.
Narottam Lamichhane,Thirupandiyur S. Udayakumar,Warren D. D'Souza,Charles B. Simone,Srinivasa R. Raghavan,Jerimy C. Polf,Javed Mahmood +6 more
TL;DR: Clinical applications of liposomal formulation and their potential imaging properties are reviewed, to enhance therapeutic effectiveness of new and established drugs that are in preclinical and clinical trials.
References
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Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside
TL;DR: Removal of detergent from mixed micelles of egg yolk phosphatidylcholine and octyl glucoside leads to formation of unilamellar phospholipid vesicles with a diameter of about 230 nm, which are highly impermeable to both anions and cations.
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Radioactive labeling of antibody: a simple and efficient method
Donald Hnatowich,W.W. Layne,R.L. Childs,D. Lanteigne,MA Davis,Thomas W. Griffin,Paul W. Doherty +6 more
TL;DR: A simple and efficient method of covalently coupling the strong chelator diethylenetriaminepentaacetic acid to proteins was developed for radiolabeling immunoglobulin G antibodies.
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Interactions of liposomes with mammalian cells
TL;DR: Although much of the literature to date has been concerned with the end applications, it seems clear that a more systematic approach to the pharmacokinetics of liposomes will be necessary.
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Work in progress: methods of contrast enhancement for NMR imaging and potential applications. A subject review.
TL;DR: Nitroxide stable free radicals are a group of synthetic, strongly paramagnetic compounds that have several characteristics that make them promising contrast enhancers.
Journal ArticleDOI
Paramagnetic contrast agents in nuclear magnetic resonance medical imaging
TL;DR: The paramagnetic contrast agents already studied are effective, and many more are potentially possible, but the most important questions to be answered are whether acute and chronic toxicity are low enough to permit research and diagnosis on humans.