Journal ArticleDOI
Localization of CRF immunoreactivity in the central nervous system of three vertebrate and one insect species.
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TLDR
The results suggest that the antigenic determinants of CRF are very similar in vertebrates and insects bespeaking their very long evolutionary history.Abstract:
By use of a specific antiserum against synthetic ovine corticotropin-releasing factor (CRF) in the peroxidase-antiperoxidase (PAP) immunocytochemical procedure (Vandesande and Dierickx 1976), CRF-like antigenic determinants were demonstrated in the central nervous system of a human fetus, the Wistar rat, the frog Rana ridibunda, and the American cockroach Periplaneta americana. The immunoreactive CRF-producing cells occur mainly in the nucleus paraventricularis of the rat, while in Rana ridibunda these cells occur in the nucleus praeopticus. Immunoreactive CRF-containing fibres were also visualized. Very clear CRF-immunoreactive products were observed in the brain as well as the corpora cardiaca (CC) and corpora allata (CA) of the cockroach Periplaneta americana. ACTH-immunoreactivity was also demonstrated in the brain-CC-CA complex of this insect. Double immunohistochemical staining (Vandesande 1983) also revealed that both the CRFand ACTH-like substances occur in different neurosecretory neurons and nerve fibres. These results suggest that the antigenic determinants of CRF are very similar in vertebrates and insects bespeaking their very long evolutionary history.read more
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Neuropeptides in the nervous system of Drosophila and other insects: multiple roles as neuromodulators and neurohormones.
TL;DR: Drosophila, in spite of its small size, is now emerging as a very favorable organism for the studies of neuropeptide function due to the arsenal of molecular genetics methods available.
Journal ArticleDOI
Environmental stress as a developmental cue : Corticotropin-releasing hormone is a proximate mediator of adaptive phenotypic plasticity in amphibian metamorphosis
TL;DR: A link between a classical neuroh hormonal stress pathway (involving corticotropin-releasing hormone, CRH) and the developmental response to habitat desiccation is demonstrated and support a central role for CRH as a neurohormonal transducer of environmental stimuli into the endocrine response which modulates the rate of metamorphosis.
Journal ArticleDOI
The neuroimmunology of stress from invertebrates to man
E. Ottaviani,C. Franceschi +1 more
TL;DR: It is concluded that stress, a highly conserved reaction remarkably similar in different species and taxa, is a fundamentally positive type of adaptive reaction.
Journal ArticleDOI
Comparative distribution of neuropeptide-immunoreactive systems in the brain of the green molly, Poecilia latipinna.
TL;DR: Topographically distinct, but often overlapping, systems of neurons and fibres displaying immunoreactivity (ir) related to a range of neuropeptides were found in most brain areas.
References
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Journal ArticleDOI
Organization of Ovine Corticotropin-Releasing Factor Immunoreactive Cells and Fibers in the Rat Brain: An Immunohistochemical Study
TL;DR: The results suggest that the PVH plays a critical role in the modulation of ACTH and beta-endorphin release from the pituitary, and that CRF-containing pathways in the brain are involved in the mediation of autonomic responses.
Journal ArticleDOI
Humoral hypothalamic control of anterior pituitary: a study with combined tissuecultures
Roger Guillemin,Barry Rosenberg +1 more
TL;DR: It appears from a study of the literature regarding possible secretion of hormones by the various endocrines in tissue cultures that, whenever hormon...
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The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain.
TL;DR: The present findings suggest that a CRF-like peptide may be involved in a neurotransmitter or neuromodulator role, as well as a hypophysiotropic role.
Journal ArticleDOI
The release of corticotrophin by anterior pituitary tissue in vitro
Murray Saffran,A. V. Schally +1 more
TL;DR: The posterior pituitary is probably involved in the response of the anterior pituitsary–adrenocortical system to stress and may be replaced by hypothalamus or sphingosine, but not by dopamine, which is structurally similar to arterenol.
Journal Article
The use of thyroglobulin to induce antigenicity to small molecules.
Skowsky Wr,Fisher Da +1 more