Journal ArticleDOI
Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed (Astragalus lentiginosus)
Reads0
Chats0
TLDR
In this article, the indolizidine alkaloids swainsonine and noxide have been identified as constituents of spotted locoweed and the inhibition of lysosomal α-mannosidase by these alkaloid compounds has been investigated.Abstract:
The indolizidine alkaloids swainsonine and swainsonine N-oxide have been isolated and identified as constituents of spotted locoweed. The inhibition of lysosomal α-mannosidase by these alkaloids su...read more
Citations
More filters
Journal ArticleDOI
(+)-Lentiginosine, a Potent and Selective Inhibitor of Amyloglucosidase: Synthetic Efforts and Disputes on Its Absolute Configuration
TL;DR: In this article, the authors present a review of several total syntheses of this alkaloid, which rely on either a chiral pool or on enantioselective approaches that have appeared since its isolation in 1990.
Journal ArticleDOI
Production of the alkaloid swainsonine by a fungal endosymbiont of the Ascomycete order Chaetothyriales in the host Ipomoea carnea.
Daniel Cook,Wesley T. Beaulieu,Ivan W. Mott,Franklin Riet-Correa,Dale R. Gardner,Daniel Grum,James A. Pfister,Keith Clay,Clairton Marcolongo-Pereira +8 more
TL;DR: It is demonstrated that I. carnea plants are infected with a fungal endosymbiont that was cultured from its seeds and which produced swainsonine in pure culture but not the calystegines, which are glycosidase inhibitors.
Book ChapterDOI
Glycosylation inhibitors for N-linked glycoproteins.
TL;DR: This chapter discusses various inhibitors that affect glycosylation of the N -linked glycoproteins, which involves rather two distinct series of reactions, the formation of lipid-linked saccharides, which donate carbohydrate to protein, and modification of the oligosaccharide chains on the protein.
Journal ArticleDOI
Abnormal glycosylation of human cellular fibronectin in the presence of swainsonine
R G Arumugham,M L Tanzer +1 more
TL;DR: The results indicate that significant changes in oligosaccharide structure had little effect upon the routing and cellular release of a typical N-asparagine-linked glycoprotein.
Journal ArticleDOI
Swainsoninine Concentrations and Endophyte Amounts of Undifilum oxytropis in Different Plant Parts of Oxytropis sericea
Daniel Cook,Dale R. Gardner,Michael H. Ralphs,James A. Pfister,Kevin D. Welch,Benedict T. Green +5 more
TL;DR: Findings provide evidence as to why plants in the same population accumulate different concentrations of swainsonine, and they have important implications for sampling of locoweed plants.
References
More filters
Journal ArticleDOI
A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens
TL;DR: In this article, a potent inhibitor of α-mannosidase was isolated from Swainsona canescens and was shown to be an indolizidinetriol by spectroscopic techniques and the relative stereochemistry was defined as 8aβ-indolizidine-lα,2α,8β-triol.
Journal ArticleDOI
Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
TL;DR: Evidence is presented to suggest that swainsonine is a reversible active site-directed inhibitor of lysosomal alpha-mannosidase.
Journal ArticleDOI
Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis.
TL;DR: It is concluded that ingestion of Swainsona induces a lysosomal storage disease, biochemically and morphologically similar to genetically determined mannosidosis.
Journal Article