Journal ArticleDOI
Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed (Astragalus lentiginosus)
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TLDR
In this article, the indolizidine alkaloids swainsonine and noxide have been identified as constituents of spotted locoweed and the inhibition of lysosomal α-mannosidase by these alkaloid compounds has been investigated.Abstract:
The indolizidine alkaloids swainsonine and swainsonine N-oxide have been isolated and identified as constituents of spotted locoweed. The inhibition of lysosomal α-mannosidase by these alkaloids su...read more
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Journal ArticleDOI
Dose response of sheep poisoned with locoweed (Oxytropis sericea).
Bryan L. Stegelmeier,Lynn F. James,Kip E. Panter,Dale R. Gardner,James A. Pfister,Michael H. Ralphs,Russell J. Molyneux +6 more
TL;DR: Both the clinical and histologic lesions, especially cerebellar lesions are suggestive of neurologic dysfunction even at low daily swainsonine doses of 0.2 mg/kg, suggesting that prolonged locoweed exposure,Even at low doses, results in significant production losses as well as histologic and functional damage.
Journal ArticleDOI
Differential inhibition by castanospermine of various insect disaccharidases
TL;DR: Among the insects studied there was no distinct relationship between enzyme inhibition and adaptation to host plants containing castanospermine or other toxic alkaloids.
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Synthesis of 3-haloindolizines by copper(II) halide mediated direct functionalization of indolizines.
Ji-Bao Xia,Shu-Li You +1 more
TL;DR: 3-Haloindolizines were synthesized via Cu(II) halide mediated halogenation of indolizine via C-H direct functionalization process under mild conditions giving 3-haloindlizines in moderate to excellent yields.
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The Indolizidine Alkaloids, Slaframine and Swainsonine: Contaminants in Animal Forages
TL;DR: Swainsonine is considered as a Mycotoxin in Rhizoctonia leguminicola and its effects on the Rat and the Pig are studied.
Journal ArticleDOI
Glycosidase inhibitors: a patent review (2008 – 2013)
TL;DR: This review summarizes and characterizes the current knowledge regarding the classes of glycosidase inhibitors that have therapeutic potential in a wide range of diseases and highlights the relevant research, patents and patent applications filed in the past years on the field.
References
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A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens
TL;DR: In this article, a potent inhibitor of α-mannosidase was isolated from Swainsona canescens and was shown to be an indolizidinetriol by spectroscopic techniques and the relative stereochemistry was defined as 8aβ-indolizidine-lα,2α,8β-triol.
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Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
TL;DR: Evidence is presented to suggest that swainsonine is a reversible active site-directed inhibitor of lysosomal alpha-mannosidase.
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Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis.
TL;DR: It is concluded that ingestion of Swainsona induces a lysosomal storage disease, biochemically and morphologically similar to genetically determined mannosidosis.
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