Journal ArticleDOI
Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed (Astragalus lentiginosus)
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TLDR
In this article, the indolizidine alkaloids swainsonine and noxide have been identified as constituents of spotted locoweed and the inhibition of lysosomal α-mannosidase by these alkaloid compounds has been investigated.Abstract:
The indolizidine alkaloids swainsonine and swainsonine N-oxide have been isolated and identified as constituents of spotted locoweed. The inhibition of lysosomal α-mannosidase by these alkaloids su...read more
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Journal ArticleDOI
Lysosomal storage disease in Sida carpinifolia toxicosis: an induced mannosidosis in horses
TL;DR: A neurological disease unrecognised until now in ponies in southern Brazil, characterised by stiff gait, muscle tremors, abdominal pain and death, seems to be similar to Swainsona, Oxytropis and Astragalus toxicosis.
Journal ArticleDOI
Characterization of a novel alpha-D-mannosidase from rat brain microsomes.
D R Tulsiani,O Touster +1 more
TL;DR: It seems possible that, in rat brain, a single mannosidase cleaves asparagine-linked high mannose oligosaccharide to form the core Man3GlcNAc2 moiety, which would then be modified by various glycosyl transferases to form complex type glycoproteins.
Book ChapterDOI
Pathobiology of neuronal storage disease.
TL;DR: This chapter discusses the consequences of these primary metabolic disturbances at the level of individual neurons or of functional groups of neurons to develop a framework for understanding those factors making specific contributions to the malfunction of neurons and to the generation of those clinical manifestations that are characteristic of these diseases.
Journal ArticleDOI
Inhibition of processing of plant N-linked oligosaccharides by castanospermine
TL;DR: In plant cells, castanospermine also prevents the removal of the outermost glucose residue as well as inhibiting glucosidase I and leads to altered glycoproteins with Glc3Man7GlcNAc2 structures.
References
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Journal ArticleDOI
A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens
TL;DR: In this article, a potent inhibitor of α-mannosidase was isolated from Swainsona canescens and was shown to be an indolizidinetriol by spectroscopic techniques and the relative stereochemistry was defined as 8aβ-indolizidine-lα,2α,8β-triol.
Journal ArticleDOI
Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
TL;DR: Evidence is presented to suggest that swainsonine is a reversible active site-directed inhibitor of lysosomal alpha-mannosidase.
Journal ArticleDOI
Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis.
TL;DR: It is concluded that ingestion of Swainsona induces a lysosomal storage disease, biochemically and morphologically similar to genetically determined mannosidosis.
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