Journal ArticleDOI
Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed (Astragalus lentiginosus)
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TLDR
In this article, the indolizidine alkaloids swainsonine and noxide have been identified as constituents of spotted locoweed and the inhibition of lysosomal α-mannosidase by these alkaloid compounds has been investigated.Abstract:
The indolizidine alkaloids swainsonine and swainsonine N-oxide have been isolated and identified as constituents of spotted locoweed. The inhibition of lysosomal α-mannosidase by these alkaloids su...read more
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Seasonal Changes in Undifilum Colonization and Swainsonine Content of Locoweeds
TL;DR: A real-time PCR technique was developed to quantify the colonization extent of Undifilum in locoweeds and to compare it to the swainsonine concentration in the plants, which was associated with high levels of endophyte DNA, except in plant reproductive tissues.
Journal ArticleDOI
Specificity of the high-mannose recognition site between Enterobacter cloacae pili adhesin and HT-29 cell membranes.
TL;DR: It is demonstrated that the 35-kDa pilus subunit is a lectin whose specificity is directed toward Man, (GlcNAc)2 oligosaccharides, which is implicated as one of the causative agents in neonatal infection and causes a septicemia thought to be initiated via the gastrointestinal tract.
Journal ArticleDOI
Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi.
TL;DR: A selection of the established and recently characterized alkaloids from the exploration of plant- and some marine-associated endophytic fungi is reviewed, with reference to alkaloid of biological significance as mentioned in this paper.
Journal ArticleDOI
Swainsonine Induces Apoptosis through Mitochondrial Pathway and Caspase Activation in Goat Trophoblasts
Yong Huang,Feng Dong,Qian Du,Hongling Zhang,Xiaomao Luo,Xiangjun Song,Xiaomin Zhao,Wenlong Zhang,Dewen Tong +8 more
TL;DR: Data suggest that SW selectively induces GTCs apoptosis via the activation of mitochondria-mediated apoptosis pathway in goat placenta cotyledons, which might contribute to placentae impairment and abortion in pregnant goats fed with SW-containing plants.
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Asymmetric formal total synthesis of (–)-swainsonine
TL;DR: In this article, a non-carbohydrate-based enantioselective approach to (−)-swainsonine is described, utilizing the kinetic resolution of α-furfuryl amide 4 and the Sharpless AD reaction of 9a as key steps.
References
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A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens
TL;DR: In this article, a potent inhibitor of α-mannosidase was isolated from Swainsona canescens and was shown to be an indolizidinetriol by spectroscopic techniques and the relative stereochemistry was defined as 8aβ-indolizidine-lα,2α,8β-triol.
Journal ArticleDOI
Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
TL;DR: Evidence is presented to suggest that swainsonine is a reversible active site-directed inhibitor of lysosomal alpha-mannosidase.
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Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis.
TL;DR: It is concluded that ingestion of Swainsona induces a lysosomal storage disease, biochemically and morphologically similar to genetically determined mannosidosis.
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