Journal ArticleDOI
Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed (Astragalus lentiginosus)
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TLDR
In this article, the indolizidine alkaloids swainsonine and noxide have been identified as constituents of spotted locoweed and the inhibition of lysosomal α-mannosidase by these alkaloid compounds has been investigated.Abstract:
The indolizidine alkaloids swainsonine and swainsonine N-oxide have been isolated and identified as constituents of spotted locoweed. The inhibition of lysosomal α-mannosidase by these alkaloids su...read more
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Slaframine and Swainsonine, Mycotoxins from Rhizoctonia Leguminicola
TL;DR: SW when compared with locoweed was found to produce similar effects on tissue glycosidases and oligosaccharides of the pig indicating that SW is the principal toxin responsible for the induction of locoism.
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Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells.
TL;DR: The results suggest that SW causes toxicity by disrupting lysosomal dysfunction, inhibiting autophagic degradation, and promoting apoptosis.
Journal ArticleDOI
A New Quinolizidine Alkaloid from Oxytropis ochrocephala
TL;DR: A new quinolizidine alkaloid, (+)-13β-butoxymatrine, was isolated from Oxytropis ochrocephala Bunge by spectroscopic methods, including extensive 1D and 2D NMR experiments.
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Maternal ingestion of locoweed: II. The ability of intoxicated ewes to discriminate their own lamb
TL;DR: The ability of ewes, exposed to locoweed during gestation and/or lactation, to discriminate their own from alien lambs was examined.
Journal ArticleDOI
Use of Herbarium Voucher Specimens To Investigate Phytochemical Composition in Poisonous Plant Research.
Daniel Cook,Stephen T. Lee,Dale R. Gardner,Russell J. Molyneux,Robert L. Johnson,Charlotte M. Taylor +5 more
TL;DR: A review of the use of herbaria in poisonous plant research can be found in this article, where the primary purpose is to highlight the chemical analysis of the herbarium specimens.
References
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Journal ArticleDOI
A Spectroscopic Investigation of Swainsonine: An α-Mannosidase Inhibitor Isolated from Swainsona canescens
TL;DR: In this article, a potent inhibitor of α-mannosidase was isolated from Swainsona canescens and was shown to be an indolizidinetriol by spectroscopic techniques and the relative stereochemistry was defined as 8aβ-indolizidine-lα,2α,8β-triol.
Journal ArticleDOI
Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.
TL;DR: Evidence is presented to suggest that swainsonine is a reversible active site-directed inhibitor of lysosomal alpha-mannosidase.
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Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis.
TL;DR: It is concluded that ingestion of Swainsona induces a lysosomal storage disease, biochemically and morphologically similar to genetically determined mannosidosis.
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