Journal ArticleDOI
Long-acting delivery systems for narcotic antagonists. 1.
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This article is published in Journal of Medicinal Chemistry.The article was published on 1973-08-01. It has received 93 citations till now.read more
Citations
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Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology.
TL;DR: The findings will be outlined according to the four major substeps of microsphere preparation by solvent extraction/evaporation, namely, incorporation of the bioactive compound, formation of the microdroplets, solvent removal and harvesting and drying the particles.
Journal ArticleDOI
Chemical and Physical Structure of Polymers as Carriers for Controlled Release of Bioactive Agents: A Review
Robert Langer,Nicholas A. Peppas +1 more
TL;DR: In a controlled release system, a drug, pesticide, or other bioactive agent is incorporated into a carrier, generally a polymeric material as mentioned in this paper, and the rate of release of the substance is determined by the properties of the polymer itself and is only weakly dependent on environmental factors.
PatentDOI
Biodegradable shape memory polymers
TL;DR: In this paper, the authors described biodegradable shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use of such materials, as well as methods of manufacturing and use thereof.
Journal ArticleDOI
One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate.
TL;DR: Results indicate that depot formulations of leuprorelin may be potentially useful in the therapy of endocrine diseases in humans and animals.
Journal ArticleDOI
Shape-memory polymers as a technology platform for biomedical applications
TL;DR: Shape-memory polymers, as described herein regarding their general principle, compositions and architectures, have developed to a technology platform that allows the tailored design of such multifunctionality and enables the development of novel medical devices that will be clinically evaluated in the near future.
References
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Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TL;DR: An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.
Journal ArticleDOI
Release of medroxyprogesterone acetate from a silicone polymer.
T. J. Roseman,William I. Higuchi +1 more
TL;DR: This study has suggested that the partition coefficient, diffusion coefficients, medroxyprogesterone acetate concentration within the polymer, and agitation conditions play important roles in the release process.
Journal Article
Release of medroxyprogesterone acetate from a silicone polymer.
T. J. Roseman,William I. Higuchi +1 more
TL;DR: In this paper, the physicochemical factors involved in the in vitro release of medroxyprogesterone acetate (MPA) a water-insoluble steroid embedded in a silicone rubber matrix was based upon a model system which considered the matric boundary diffusion layer.
Journal ArticleDOI
Drug Release from Compressed Hydrophilic Matrices
H. Lapidus,Nicholas G. Lordi +1 more
TL;DR: Comparison of the rates of drug release from the planar surface of a compressed polymer matrix with theoretically predicted values was made and the integrity of the hydrated polymer was maintained, and the release of drug was diffusion controlled.