Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms.
Bruno Silva Andrade,Sérgio Siqueira,Wagner Rodrigues de Assis Soares,Fernanda de Souza Rangel,Fernanda de Souza Rangel,Naiane Oliveira Santos,Andria Dos Santos Freitas,Andria Dos Santos Freitas,Priscila Ribeiro da Silveira,Sandeep Tiwari,Khalid J. Alzahrani,Aristóteles Góes-Neto,Vasco Azevedo,Preetam Ghosh,Debmalya Barh +14 more
Reads0
Chats0
TLDR
In this paper, a comprehensive review of adverse post-COVID health outcomes and potential long-coVID effects was conducted, and the authors observed that such adverse outcomes were not localized.Abstract:
The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-term care of COVID-19 survivors. It is thus imperative to study post-COVID (i.e., short-term) and long-COVID (i.e., long-term) effects, specifically as local and systemic pathophysiological outcomes of other coronavirus-related diseases (such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS)) were well-cataloged. We conducted a comprehensive review of adverse post-COVID health outcomes and potential long-COVID effects. We observed that such adverse outcomes were not localized. Rather, they affected different human systems, including: (i) immune system (e.g., Guillain-Barre syndrome, rheumatoid arthritis, pediatric inflammatory multisystem syndromes such as Kawasaki disease), (ii) hematological system (vascular hemostasis, blood coagulation), (iii) pulmonary system (respiratory failure, pulmonary thromboembolism, pulmonary embolism, pneumonia, pulmonary vascular damage, pulmonary fibrosis), (iv) cardiovascular system (myocardial hypertrophy, coronary artery atherosclerosis, focal myocardial fibrosis, acute myocardial infarction, cardiac hypertrophy), (v) gastrointestinal, hepatic, and renal systems (diarrhea, nausea/vomiting, abdominal pain, anorexia, acid reflux, gastrointestinal hemorrhage, lack of appetite/constipation), (vi) skeletomuscular system (immune-mediated skin diseases, psoriasis, lupus), (vii) nervous system (loss of taste/smell/hearing, headaches, spasms, convulsions, confusion, visual impairment, nerve pain, dizziness, impaired consciousness, nausea/vomiting, hemiplegia, ataxia, stroke, cerebral hemorrhage), (viii) mental health (stress, depression and anxiety). We additionally hypothesized mechanisms of action by investigating possible molecular mechanisms associated with these disease outcomes/symptoms. Overall, the COVID-19 pathology is still characterized by cytokine storm that results to endothelial inflammation, microvascular thrombosis, and multiple organ failures.read more
Citations
More filters
Journal ArticleDOI
Pathophysiology and mechanism of long COVID: a comprehensive review
Diego Castanares-Zapatero,Patrice Chalon,L. Winfield Kohn,Marie Dauvrin,Jens Detollenaere,Charline Maertens de Noordhout,C. Primus-de Jong,Irina Cleemput,K. Van den Heede +8 more
TL;DR: A comprehensive review of the putative pathophysiology underlying the persisting symptoms of long COVID found that organ damage from the acute infection phase likely accounts for symptoms, and specific long-lasting inflammatory mechanisms have been proposed, as well.
Journal ArticleDOI
Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study
Salma Charfeddine,Hassen Ibn Hadj Amor,Jihen Jdidi,Slim Torjmen,Salma Kraiem,Rania Hammami,Amine Bahloul,Nesrine Kallel,N. Moussa,Imen Touil,Aiman Ghrab,Jamel Elghoul,Zineb Meddeb,Yamina Thabet,Samir Kammoun,Kamel Bouslama,Sami Milouchi,Salem Ben Abdessalem,Leila Abid +18 more
TL;DR: In this paper, the authors focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated to endothelial dysfunction.
Journal ArticleDOI
Evaluation of Anti-SARS-Cov-2 S-RBD IgG Antibodies after COVID-19 mRNA BNT162b2 Vaccine
Bruna Lo Sasso,Rosaria Vincenza Giglio,Matteo Vidali,Concetta Scazzone,Giulia Bivona,Caterina Maria Gambino,Anna Maria Ciaccio,Luisa Agnello,Marcello Ciaccio +8 more
TL;DR: In this paper, the authors evaluated anti-RBD IgG levels by indirect chemiluminescence immunoassay on Maglumi 800 (SNIBE, California) in 2248 vaccinated subjects without previous SARS-CoV-2 infection, 91 vaccinated individuals recovered from COVID-19, and 268 individuals who had not been vaccinated.
Journal ArticleDOI
Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems
Valeria Visco,Carolina Vitale,Antonella Rispoli,Carmine Izzo,Nicola Virtuoso,G. Ferruzzi,Mario Santopietro,Americo Melfi,Mariangela Rusciano,Angelantonio Maglio,Paola Di Pietro,Albino Carrizzo,Gennaro Galasso,Alessandro Vatrella,Carmine Vecchione,Michele Ciccarelli +15 more
TL;DR: Long COVID is a complex syndrome with protracted heterogeneous symptoms, and patients who experience post-COVID-19 sequelae require personalized treatment as well as ongoing support.
Journal ArticleDOI
COVID-19 2022 update: transition of the pandemic to the endemic phase
Michela Biancolella,Vito Luigi Colona,Ruty Mehrian-Shai,Jessica Watt,Lucio Luzzatto,Giuseppe Novelli,Juergen K. V. Reichardt +6 more
TL;DR: In this paper , the authors reviewed the current state of research into the disease with focus on its history, human genetics and genomics and the transition from the pandemic to the endemic phase.
References
More filters
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
Safiya Richardson,Safiya Richardson,Jamie S. Hirsch,Jamie S. Hirsch,Mangala Narasimhan,James M. Crawford,Thomas McGinn,Thomas McGinn,Karina W. Davidson,Karina W. Davidson,Douglas P. Barnaby,Douglas P. Barnaby,Lance B Becker,John Chelico,John Chelico,Stuart L. Cohen,Stuart L. Cohen,Jennifer Cookingham,Kevin Coppa,Michael A Diefenbach,Andrew J. Dominello,Joan Duer-Hefele,Louise Falzon,Jordan Gitlin,Negin Hajizadeh,Negin Hajizadeh,Tiffany G. Harvin,David Hirschwerk,Eun Ji Kim,Eun Ji Kim,Zachary Kozel,Lyndonna Marrast,Lyndonna Marrast,Jazmin N. Mogavero,Gabrielle A. Osorio,Michael Qiu,Theodoros P. Zanos +36 more
TL;DR: This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area and assesses outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death.
Journal ArticleDOI
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Ling Mao,Huijuan Jin,Mengdie Wang,Yu Hu,Shengcai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Xiaoping Miao,Yanan Li,Bo Hu +12 more
TL;DR: During the epidemic period of COVID-19, clinicians should suspect severe acute respiratory syndrome coronavirus 2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and lose the chance to treat and prevent further transmission.
Journal ArticleDOI
Endothelial cell infection and endotheliitis in COVID-19.
Zsuzsanna Varga,Andreas J. Flammer,Peter Steiger,Martina Haberecker,Rea Andermatt,Annelies S. Zinkernagel,Mandeep R. Mehra,Reto A. Schuepbach,Frank Ruschitzka,Holger Moch +9 more
TL;DR: The vascular endothelium is an active paracrine, endocrine, and Endothelial cell infection and endotheliitis in COVID-19 and recruitment of immune cells can result in widespread endothelial dysfunction associated with apoptosis.
Related Papers (5)
6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.
Chaolin Huang,Lixue Huang,Lixue Huang,Yeming Wang,Xia Li,Lili Ren,Xiaoying Gu,Xiaoying Gu,Liang Kang,Lili Guo,Min Liu,Xing Zhou,Jianfeng Luo,Zhenghui Huang,Shengjin Tu,Yue Zhao,Li Chen,Decui Xu,Yanping Li,Caihong Li,Lu Peng,Yong Mei Li,Wuxiang Xie,Dan Cui,Dan Cui,Lianhan Shang,Lianhan Shang,Guohui Fan,Guohui Fan,Jiuyang Xu,Geng Wang,Geng Wang,Ying Wang,Jingchuan Zhong,Chen Wang,Chen Wang,Jianwei Wang,Dingyu Zhang,Bin Cao +38 more
Post-acute COVID-19 syndrome.
Ani Nalbandian,Kartik Sehgal,Kartik Sehgal,Aakriti Gupta,Aakriti Gupta,Mahesh V. Madhavan,Claire McGroder,Jacob S. Stevens,Joshua R. Cook,Anna S. Nordvig,Daniel Shalev,Tejasav S. Sehrawat,Neha Ahluwalia,Behnood Bikdeli,Donald Dietz,Caroline Der-Nigoghossian,Nadia Liyanage-Don,Gregg F. Rosner,Elana J. Bernstein,Sumit Mohan,Akinpelumi A Beckley,David S. Seres,Toni K. Choueiri,Toni K. Choueiri,Nir Uriel,John C. Ausiello,Domenico Accili,Daniel E. Freedberg,Matthew R. Baldwin,Allan Schwartz,Daniel Brodie,Christine Kim Garcia,Mitchell S.V. Elkind,Jean M. Connors,Jean M. Connors,John P. Bilezikian,Donald W. Landry,Elaine Wan +37 more